Direct access to pyrido/pyrrolo[2,1-b]quinazolin-9(1H)-ones through silver-mediated intramolecular alkyne hydroamination reactions

We report a synthetic methodology for the construction of the fused heterocyclic compounds pyrido[2,1-b]quinazolin-9(1H)-ones and pyrrolo[2,1-b]quinazolin-9(1H)-ones through an AgOTf-catalyzed intramolecular alkyne hydroamination reaction. The methodology is applicable to a wide scope of substrates...

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Detalles Bibliográficos
Autores principales: Wang, Hengshuai, Jiao, Shengchao, Chen, Kerong, Zhang, Xu, Zhao, Linxiang, Liu, Dan, Zhou, Yu, Liu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2015
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419559/
https://www.ncbi.nlm.nih.gov/pubmed/25977715
http://dx.doi.org/10.3762/bjoc.11.47
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author Wang, Hengshuai
Jiao, Shengchao
Chen, Kerong
Zhang, Xu
Zhao, Linxiang
Liu, Dan
Zhou, Yu
Liu, Hong
author_facet Wang, Hengshuai
Jiao, Shengchao
Chen, Kerong
Zhang, Xu
Zhao, Linxiang
Liu, Dan
Zhou, Yu
Liu, Hong
author_sort Wang, Hengshuai
collection PubMed
description We report a synthetic methodology for the construction of the fused heterocyclic compounds pyrido[2,1-b]quinazolin-9(1H)-ones and pyrrolo[2,1-b]quinazolin-9(1H)-ones through an AgOTf-catalyzed intramolecular alkyne hydroamination reaction. The methodology is applicable to a wide scope of substrates and produces a series of fused quinazolinone heterocycles in good to excellent yields.
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spelling pubmed-44195592015-05-14 Direct access to pyrido/pyrrolo[2,1-b]quinazolin-9(1H)-ones through silver-mediated intramolecular alkyne hydroamination reactions Wang, Hengshuai Jiao, Shengchao Chen, Kerong Zhang, Xu Zhao, Linxiang Liu, Dan Zhou, Yu Liu, Hong Beilstein J Org Chem Full Research Paper We report a synthetic methodology for the construction of the fused heterocyclic compounds pyrido[2,1-b]quinazolin-9(1H)-ones and pyrrolo[2,1-b]quinazolin-9(1H)-ones through an AgOTf-catalyzed intramolecular alkyne hydroamination reaction. The methodology is applicable to a wide scope of substrates and produces a series of fused quinazolinone heterocycles in good to excellent yields. Beilstein-Institut 2015-03-30 /pmc/articles/PMC4419559/ /pubmed/25977715 http://dx.doi.org/10.3762/bjoc.11.47 Text en Copyright © 2015, Wang et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Wang, Hengshuai
Jiao, Shengchao
Chen, Kerong
Zhang, Xu
Zhao, Linxiang
Liu, Dan
Zhou, Yu
Liu, Hong
Direct access to pyrido/pyrrolo[2,1-b]quinazolin-9(1H)-ones through silver-mediated intramolecular alkyne hydroamination reactions
title Direct access to pyrido/pyrrolo[2,1-b]quinazolin-9(1H)-ones through silver-mediated intramolecular alkyne hydroamination reactions
title_full Direct access to pyrido/pyrrolo[2,1-b]quinazolin-9(1H)-ones through silver-mediated intramolecular alkyne hydroamination reactions
title_fullStr Direct access to pyrido/pyrrolo[2,1-b]quinazolin-9(1H)-ones through silver-mediated intramolecular alkyne hydroamination reactions
title_full_unstemmed Direct access to pyrido/pyrrolo[2,1-b]quinazolin-9(1H)-ones through silver-mediated intramolecular alkyne hydroamination reactions
title_short Direct access to pyrido/pyrrolo[2,1-b]quinazolin-9(1H)-ones through silver-mediated intramolecular alkyne hydroamination reactions
title_sort direct access to pyrido/pyrrolo[2,1-b]quinazolin-9(1h)-ones through silver-mediated intramolecular alkyne hydroamination reactions
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419559/
https://www.ncbi.nlm.nih.gov/pubmed/25977715
http://dx.doi.org/10.3762/bjoc.11.47
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