Oral Field Cancerization: An Update on Current Concepts

There always exists a field with genetically altered cells with a high risk of developing premalignant and malignant lesions. It may often happen that an individual stem cell is genetically altered and can cause the formation of a clone or a patch which is likely to turn into a tumor. This explains...

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Detalles Bibliográficos
Autores principales: Mohan, Meenakshi, Jagannathan, Nithya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419611/
https://www.ncbi.nlm.nih.gov/pubmed/25992232
http://dx.doi.org/10.4081/oncol.2014.244
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author Mohan, Meenakshi
Jagannathan, Nithya
author_facet Mohan, Meenakshi
Jagannathan, Nithya
author_sort Mohan, Meenakshi
collection PubMed
description There always exists a field with genetically altered cells with a high risk of developing premalignant and malignant lesions. It may often happen that an individual stem cell is genetically altered and can cause the formation of a clone or a patch which is likely to turn into a tumor. This explains the higher recurrence rates following tumor resections. It is essential to identify and to treat this field in order to have greater chances to prevent cancer and achieve a better outcome. This article reports concepts, theories and markers for the assessment of field cancerization.
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spelling pubmed-44196112015-05-19 Oral Field Cancerization: An Update on Current Concepts Mohan, Meenakshi Jagannathan, Nithya Oncol Rev Review There always exists a field with genetically altered cells with a high risk of developing premalignant and malignant lesions. It may often happen that an individual stem cell is genetically altered and can cause the formation of a clone or a patch which is likely to turn into a tumor. This explains the higher recurrence rates following tumor resections. It is essential to identify and to treat this field in order to have greater chances to prevent cancer and achieve a better outcome. This article reports concepts, theories and markers for the assessment of field cancerization. PAGEPress Publications, Pavia, Italy 2014-06-30 /pmc/articles/PMC4419611/ /pubmed/25992232 http://dx.doi.org/10.4081/oncol.2014.244 Text en ©Copyright M. Mohan and N. Jagannathan http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Mohan, Meenakshi
Jagannathan, Nithya
Oral Field Cancerization: An Update on Current Concepts
title Oral Field Cancerization: An Update on Current Concepts
title_full Oral Field Cancerization: An Update on Current Concepts
title_fullStr Oral Field Cancerization: An Update on Current Concepts
title_full_unstemmed Oral Field Cancerization: An Update on Current Concepts
title_short Oral Field Cancerization: An Update on Current Concepts
title_sort oral field cancerization: an update on current concepts
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419611/
https://www.ncbi.nlm.nih.gov/pubmed/25992232
http://dx.doi.org/10.4081/oncol.2014.244
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