Chemotherapy and target therapy as neo-adjuvant approach for initially unresectable colorectal liver metastases

Although surgery is the most effective treatment for liver metastases in colorectal cancer patients, only 15–20% of these patients are suitable for a radical surgical approach, and metastases recurrence may occur at follow up. In the last decade, the use of pre-operative chemotherapy in combination...

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Autores principales: Rossi, Luigi, Zullo, Angelo, Zoratto, Federica, Papa, Anselmo, Strudel, Martina, Colonna, Maria, Tomao, Silverio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419640/
https://www.ncbi.nlm.nih.gov/pubmed/25992208
http://dx.doi.org/10.4081/oncol.2012.e6
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author Rossi, Luigi
Zullo, Angelo
Zoratto, Federica
Papa, Anselmo
Strudel, Martina
Colonna, Maria
Tomao, Silverio
author_facet Rossi, Luigi
Zullo, Angelo
Zoratto, Federica
Papa, Anselmo
Strudel, Martina
Colonna, Maria
Tomao, Silverio
author_sort Rossi, Luigi
collection PubMed
description Although surgery is the most effective treatment for liver metastases in colorectal cancer patients, only 15–20% of these patients are suitable for a radical surgical approach, and metastases recurrence may occur at follow up. In the last decade, the use of pre-operative chemotherapy in combination with new biological drugs has been introduced. We reviewed data of neo-adjuvant chemotherapy strategies aimed at increasing the resection rate of liver metastases in colorectal cancer patients who were initially considered unresectable.
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spelling pubmed-44196402015-05-19 Chemotherapy and target therapy as neo-adjuvant approach for initially unresectable colorectal liver metastases Rossi, Luigi Zullo, Angelo Zoratto, Federica Papa, Anselmo Strudel, Martina Colonna, Maria Tomao, Silverio Oncol Rev Review Although surgery is the most effective treatment for liver metastases in colorectal cancer patients, only 15–20% of these patients are suitable for a radical surgical approach, and metastases recurrence may occur at follow up. In the last decade, the use of pre-operative chemotherapy in combination with new biological drugs has been introduced. We reviewed data of neo-adjuvant chemotherapy strategies aimed at increasing the resection rate of liver metastases in colorectal cancer patients who were initially considered unresectable. PAGEPress Publications 2012-06-14 /pmc/articles/PMC4419640/ /pubmed/25992208 http://dx.doi.org/10.4081/oncol.2012.e6 Text en ©Copyright L. Rossi et al., 2012 This work is licensed under a Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0). Licensee PAGEPress, Italy
spellingShingle Review
Rossi, Luigi
Zullo, Angelo
Zoratto, Federica
Papa, Anselmo
Strudel, Martina
Colonna, Maria
Tomao, Silverio
Chemotherapy and target therapy as neo-adjuvant approach for initially unresectable colorectal liver metastases
title Chemotherapy and target therapy as neo-adjuvant approach for initially unresectable colorectal liver metastases
title_full Chemotherapy and target therapy as neo-adjuvant approach for initially unresectable colorectal liver metastases
title_fullStr Chemotherapy and target therapy as neo-adjuvant approach for initially unresectable colorectal liver metastases
title_full_unstemmed Chemotherapy and target therapy as neo-adjuvant approach for initially unresectable colorectal liver metastases
title_short Chemotherapy and target therapy as neo-adjuvant approach for initially unresectable colorectal liver metastases
title_sort chemotherapy and target therapy as neo-adjuvant approach for initially unresectable colorectal liver metastases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419640/
https://www.ncbi.nlm.nih.gov/pubmed/25992208
http://dx.doi.org/10.4081/oncol.2012.e6
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