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OASes and STING: Adaptive Evolution in Concert

OAS (2′–5′-oligoadenylate synthases) proteins and cyclic GMP–AMP synthase (cGAS, gene symbol: MB21D1) patrol the cytoplasm for the presence of foreign nucleic acids. Upon binding to double-stranded RNA or double-stranded DNA, OAS proteins and cGAS produce nucleotide second messengers to activate RNa...

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Detalles Bibliográficos
Autores principales:	Mozzi, Alessandra, Pontremoli, Chiara, Forni, Diego, Clerici, Mario, Pozzoli, Uberto, Bresolin, Nereo, Cagliani, Rachele, Sironi, Manuela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419793/ https://www.ncbi.nlm.nih.gov/pubmed/25752600 http://dx.doi.org/10.1093/gbe/evv046

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