Cargando…

Of Monkeys and Men: Immunomic Profiling of Sera from Humans and Non-Human Primates Resistant to Schistosomiasis Reveals Novel Potential Vaccine Candidates

Schistosoma haematobium affects more than 100 million people throughout Africa and is the causative agent of urogenital schistosomiasis. The parasite is strongly associated with urothelial cancer in infected individuals and as such is designated a group I carcinogen by the International Agency for R...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pearson, Mark S., Becker, Luke, Driguez, Patrick, Young, Neil D., Gaze, Soraya, Mendes, Tiago, Li, Xiao-Hong, Doolan, Denise L., Midzi, Nicholas, Mduluza, Takafira, McManus, Donald P., Wilson, R. Alan, Bethony, Jeffrey M., Nausch, Norman, Mutapi, Francisca, Felgner, Philip L., Loukas, Alex
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2015
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419842/ https://www.ncbi.nlm.nih.gov/pubmed/25999951 http://dx.doi.org/10.3389/fimmu.2015.00213

Ejemplares similares

Schistosomiasis vaccine discovery using immunomics
por: Driguez, Patrick, et al.
Publicado: (2010)

Immunomics-Guided Antigen Discovery for Praziquantel-Induced Vaccination in Urogenital Human Schistosomiasis
por: Pearson, Mark S., et al.
Publicado: (2021)

Identifying and Evaluating Field Indicators of Urogenital Schistosomiasis-Related Morbidity in Preschool-Aged Children
por: Wami, Welcome M., et al.
Publicado: (2015)

Regulatory and Activated T Cells in Human Schistosoma haematobium Infections
por: Nausch, Norman, et al.
Publicado: (2011)

Integrated Analysis of Innate, Th1, Th2, Th17, and Regulatory Cytokines Identifies Changes in Immune Polarisation Following Treatment of Human Schistosomiasis
por: Bourke, Claire D., et al.
Publicado: (2013)

Comparative Assessment of Health Benefits of Praziquantel Treatment of Urogenital Schistosomiasis in Preschool and Primary School-Aged Children
por: Wami, Welcome M., et al.
Publicado: (2016)

An Immunomics Approach to Schistosome Antigen Discovery: Antibody Signatures of Naturally Resistant and Chronically Infected Individuals from Endemic Areas
por: Gaze, Soraya, et al.
Publicado: (2014)

Immunomics-guided discovery of serum and urine antibodies for diagnosing urogenital schistosomiasis: a biomarker identification study
por: Pearson, Mark S, et al.
Publicado: (2021)

Sources of heterogeneity in human monocyte subsets
por: Appleby, Laura J., et al.
Publicado: (2013)

Association between Micronutrients (Vitamin A, D, Iron) and Schistosome-Specific Cytokine Responses in Zimbabweans Exposed to Schistosoma haematobium
por: Reilly, Liam, et al.
Publicado: (2012)

Putting the treatment of paediatric schistosomiasis into context
por: Mduluza, Takafira, et al.
Publicado: (2017)

Field evaluation of a new antibody-based diagnostic for Schistosoma haematobium and S. mansoni at the point-of-care in northeast Zimbabwe
por: Nausch, Norman, et al.
Publicado: (2014)

Group 2 Innate Lymphoid Cell Proportions Are Diminished in Young Helminth Infected Children and Restored by Curative Anti-helminthic Treatment
por: Nausch, Norman, et al.
Publicado: (2015)

Exposure, infection, systemic cytokine levels and antibody responses in young children concurrently exposed to schistosomiasis and malaria
por: IMAI, NATSUKO, et al.
Publicado: (2011)

Soluble CD23 Levels are Inversely Associated with Atopy and Parasite-Specific IgE Levels but Not with Polyclonal IgE Levels in People Exposed to Helminth Infection
por: Rujeni, Nadine, et al.
Publicado: (2013)

Pharmacogenetics of Praziquantel Metabolism: Evaluating the Cytochrome P450 Genes of Zimbabwean Patients During a Schistosomiasis Treatment
por: Zdesenko, Grace, et al.
Publicado: (2022)

Schistosoma haematobium Treatment in 1–5 Year Old Children: Safety and Efficacy of the Antihelminthic Drug Praziquantel
por: Mutapi, Francisca, et al.
Publicado: (2011)

Atopy Is Inversely Related to Schistosome Infection Intensity: A Comparative Study in Zimbabwean Villages with Distinct Levels of Schistosoma haematobium Infection
por: Rujeni, Nadine, et al.
Publicado: (2012)

Circulating cytokine levels and antibody responses to human Schistosoma haematobium: IL-5 and IL-10 levels depend upon age and infection status
por: Milner, T, et al.
Publicado: (2010)

Association of schistosomiasis and risk of prostate cancer development in residents of Murehwa rural community, Zimbabwe
por: Choto, Emilia T., et al.
Publicado: (2020)

CD16 Expression on Monocytes in Healthy Individuals but Not Schistosome-Infected Patients Is Positively Associated with Levels of Parasite-Specific IgG and IgG1
por: Appleby, Laura J., et al.
Publicado: (2014)

Cytokine Responses to the Anti-schistosome Vaccine Candidate Antigen Glutathione-S-transferase Vary with Host Age and Are Boosted by Praziquantel Treatment
por: Bourke, Claire D., et al.
Publicado: (2014)

Chitinase 3-Like 1 Protein Levels Are Elevated in Schistosoma haematobium Infected Children
por: Appleby, Laura J., et al.
Publicado: (2012)

Comparing parasitological vs serological determination of Schistosoma haematobium infection prevalence in preschool and primary school-aged children: implications for control programmes
por: WAMI, WELCOME M., et al.
Publicado: (2014)

Proportions of CD4+ memory T cells are altered in individuals chronically infected with Schistosoma haematobium
por: Nausch, Norman, et al.
Publicado: (2012)

Age-Related Patterns in Human Myeloid Dendritic Cell Populations in People Exposed to Schistosoma haematobium Infection
por: Nausch, Norman, et al.
Publicado: (2012)

Immunological Consequences of Antihelminthic Treatment in Preschool Children Exposed to Urogenital Schistosome Infection
por: Rujeni, Nadine, et al.
Publicado: (2013)

Down Regulation of the TCR Complex CD3ζ-Chain on CD3+ T Cells: A Potential Mechanism for Helminth-Mediated Immune Modulation
por: Appleby, Laura J., et al.
Publicado: (2015)

Schistosoma haematobium infection levels determine the effect of praziquantel treatment on anti-schistosome and anti-mite antibodies
por: RUJENI, N, et al.
Publicado: (2012)

Differences in the Faecal Microbiome in Schistosoma haematobium Infected Children vs. Uninfected Children
por: Kay, Gemma Louise, et al.
Publicado: (2015)

Seroepidemiology of Plasmodium species infections in Zimbabwean population
por: Amanfo, Seth A., et al.
Publicado: (2016)

The Identification and Characterization of Immunoreactive Fungal Proteins Recognized by Sera from Zimbabweans Sensitized to Fungi
por: Pfavayi, Lorraine Tsitsi, et al.
Publicado: (2022)

Decrease in Seminal HIV-1 RNA Load After Praziquantel Treatment of Urogenital Schistosomiasis Coinfection in HIV-Positive Men—An Observational Study
por: Midzi, Nicholas, et al.
Publicado: (2017)

Distribution of Schistosomiasis and Soil Transmitted Helminthiasis in Zimbabwe: Towards a National Plan of Action for Control and Elimination
por: Midzi, Nicholas, et al.
Publicado: (2014)

Immuno-epidemiology of human Schistosoma haematobium infection: preferential IgG3 antibody responsiveness to a recombinant antigen dependent on age and parasite burden
por: Mutapi, Francisca, et al.
Publicado: (2006)

Cytokine responses to Schistosoma haematobium in a Zimbabwean population: contrasting profiles for IFN-γ, IL-4, IL-5 and IL-10 with age
por: Mutapi, Francisca, et al.
Publicado: (2007)

Benefits of annual chemotherapeutic control of schistosomiasis on the development of protective immunity
por: Chisango, Tawanda J., et al.
Publicado: (2019)

Multiplex peptide microarray profiling of antibody reactivity against neglected tropical diseases derived B-cell epitopes for serodiagnosis in Zimbabwe
por: Vengesai, Arthur, et al.
Publicado: (2022)

Schistosome Infection Intensity Is Inversely Related to Auto-Reactive Antibody Levels
por: Mutapi, Francisca, et al.
Publicado: (2011)

Frequency distribution of cytokine and associated transcription factor single nucleotide polymorphisms in Zimbabweans: Impact on schistosome infection and cytokine levels
por: Hanton, Andrew John, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_43aqnrrt8rjdkem7bhn41d26dc