Crystal structure of 5,11-di­hydro­pyrido[2,3-b][1,4]benzodiazepin-6-one

The title compound, C(12)H(9)N(3)O, is an inter­mediate in the synthesis of the muscarinic M2 receptor antagonist AFDX-384. The seven-membered ring adopts a boat conformation and the dihedral angle between the planes of the aromatic rings is 41.51 (9)°. In the crystal, mol­ecules are linked into [00...

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Detalles Bibliográficos
Autores principales: Riad, Noura M., Zlotos, Darius P., Holzgrabe, Ulrike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2015
Materias:
Data Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420050/
https://www.ncbi.nlm.nih.gov/pubmed/25995917
http://dx.doi.org/10.1107/S2056989015006817
Descripción
Sumario:The title compound, C(12)H(9)N(3)O, is an inter­mediate in the synthesis of the muscarinic M2 receptor antagonist AFDX-384. The seven-membered ring adopts a boat conformation and the dihedral angle between the planes of the aromatic rings is 41.51 (9)°. In the crystal, mol­ecules are linked into [001] chains of alternating inversion dimers formed by pairs of N—H⋯O hydrogen bonds and pairs of N—H⋯N hydrogen bonds. In both cases, R (2) (2)(8) loops are generated.

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