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CSF Proteomics Identifies Specific and Shared Pathways for Multiple Sclerosis Clinical Subtypes
Multiple sclerosis (MS) is an immune-mediated, neuro-inflammatory, demyelinating and neurodegenerative disease of the central nervous system (CNS) with a heterogeneous clinical presentation and course. There is a remarkable phenotypic heterogeneity in MS, and the molecular mechanisms underlying it r...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420287/ https://www.ncbi.nlm.nih.gov/pubmed/25942430 http://dx.doi.org/10.1371/journal.pone.0122045 |
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author | Avsar, Timucin Durası, İlknur Melis Uygunoğlu, Uğur Tütüncü, Melih Demirci, Nuri Onat Saip, Sabahattin Sezerman, O. Uğur Siva, Aksel Tahir Turanlı, Eda |
author_facet | Avsar, Timucin Durası, İlknur Melis Uygunoğlu, Uğur Tütüncü, Melih Demirci, Nuri Onat Saip, Sabahattin Sezerman, O. Uğur Siva, Aksel Tahir Turanlı, Eda |
author_sort | Avsar, Timucin |
collection | PubMed |
description | Multiple sclerosis (MS) is an immune-mediated, neuro-inflammatory, demyelinating and neurodegenerative disease of the central nervous system (CNS) with a heterogeneous clinical presentation and course. There is a remarkable phenotypic heterogeneity in MS, and the molecular mechanisms underlying it remain unknown. We aimed to investigate further the etiopathogenesis related molecular pathways in subclinical types of MS using proteomic and bioinformatics approaches in cerebrospinal fluids of patients with clinically isolated syndrome, relapsing remitting MS and progressive MS (n=179). Comparison of disease groups with controls revealed a total of 151 proteins that are differentially expressed in clinically different MS subtypes. KEGG analysis using PANOGA tool revealed the disease related pathways including aldosterone-regulated sodium reabsorption (p=8.02x10(-5)) which is important in the immune cell migration, renin-angiotensin (p=6.88x10(-5)) system that induces Th17 dependent immunity, notch signaling (p=1.83x10(-10)) pathway indicating the activated remyelination and vitamin digestion and absorption pathways (p=1.73x10(-5)). An emerging theme from our studies is that whilst all MS clinical forms share common biological pathways, there are also clinical subtypes specific and pathophysiology related pathways which may have further therapeutic implications. |
format | Online Article Text |
id | pubmed-4420287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-44202872015-05-12 CSF Proteomics Identifies Specific and Shared Pathways for Multiple Sclerosis Clinical Subtypes Avsar, Timucin Durası, İlknur Melis Uygunoğlu, Uğur Tütüncü, Melih Demirci, Nuri Onat Saip, Sabahattin Sezerman, O. Uğur Siva, Aksel Tahir Turanlı, Eda PLoS One Research Article Multiple sclerosis (MS) is an immune-mediated, neuro-inflammatory, demyelinating and neurodegenerative disease of the central nervous system (CNS) with a heterogeneous clinical presentation and course. There is a remarkable phenotypic heterogeneity in MS, and the molecular mechanisms underlying it remain unknown. We aimed to investigate further the etiopathogenesis related molecular pathways in subclinical types of MS using proteomic and bioinformatics approaches in cerebrospinal fluids of patients with clinically isolated syndrome, relapsing remitting MS and progressive MS (n=179). Comparison of disease groups with controls revealed a total of 151 proteins that are differentially expressed in clinically different MS subtypes. KEGG analysis using PANOGA tool revealed the disease related pathways including aldosterone-regulated sodium reabsorption (p=8.02x10(-5)) which is important in the immune cell migration, renin-angiotensin (p=6.88x10(-5)) system that induces Th17 dependent immunity, notch signaling (p=1.83x10(-10)) pathway indicating the activated remyelination and vitamin digestion and absorption pathways (p=1.73x10(-5)). An emerging theme from our studies is that whilst all MS clinical forms share common biological pathways, there are also clinical subtypes specific and pathophysiology related pathways which may have further therapeutic implications. Public Library of Science 2015-05-05 /pmc/articles/PMC4420287/ /pubmed/25942430 http://dx.doi.org/10.1371/journal.pone.0122045 Text en © 2015 Avsar et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Avsar, Timucin Durası, İlknur Melis Uygunoğlu, Uğur Tütüncü, Melih Demirci, Nuri Onat Saip, Sabahattin Sezerman, O. Uğur Siva, Aksel Tahir Turanlı, Eda CSF Proteomics Identifies Specific and Shared Pathways for Multiple Sclerosis Clinical Subtypes |
title | CSF Proteomics Identifies Specific and Shared Pathways for Multiple Sclerosis Clinical Subtypes |
title_full | CSF Proteomics Identifies Specific and Shared Pathways for Multiple Sclerosis Clinical Subtypes |
title_fullStr | CSF Proteomics Identifies Specific and Shared Pathways for Multiple Sclerosis Clinical Subtypes |
title_full_unstemmed | CSF Proteomics Identifies Specific and Shared Pathways for Multiple Sclerosis Clinical Subtypes |
title_short | CSF Proteomics Identifies Specific and Shared Pathways for Multiple Sclerosis Clinical Subtypes |
title_sort | csf proteomics identifies specific and shared pathways for multiple sclerosis clinical subtypes |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420287/ https://www.ncbi.nlm.nih.gov/pubmed/25942430 http://dx.doi.org/10.1371/journal.pone.0122045 |
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