IGF-1 drives chromogranin A secretion via activation of Arf1 in human neuroendocrine tumour cells

Hypersecretion is the major symptom of functional neuroendocrine tumours. The mechanisms that contribute to this excessive secretion of hormones are still elusive. A key event in secretion is the exit of secretory products from the Golgi apparatus. ADP-ribosylation factor (Arf) GTPases are known to...

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Detalles Bibliográficos
Autores principales: Münzberg, Christin, Höhn, Katharina, Krndija, Denis, Maaß, Ulrike, Bartsch, Detlef K, Slater, Emily P, Oswald, Franz, Walther, Paul, Seufferlein, Thomas, von Wichert, Götz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420598/
https://www.ncbi.nlm.nih.gov/pubmed/25754106
http://dx.doi.org/10.1111/jcmm.12473

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