Molecular PET Imaging of Cyclophosphamide Induced Apoptosis with (18)F-ML-8

In this paper, a novel small-molecular apoptotic PET imaging probe, (18)F-ML-8 with a malonate motif structure, is presented and discussed. After study, the small tracer that belongs to a member of ApoSense family is proved to be capable of imaging merely apoptotic regions in the CTX treated tumor-b...

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Detalles Bibliográficos
Autores principales: Yao, Shaobo, Hu, Kongzhen, Tang, Ganghua, Gao, Siyuan, Tang, Caihua, Yao, Baoguo, Nie, Dahong, Sun, Ting, Jiang, Shende
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420799/
https://www.ncbi.nlm.nih.gov/pubmed/25977920
http://dx.doi.org/10.1155/2015/317403
Descripción
Sumario:In this paper, a novel small-molecular apoptotic PET imaging probe, (18)F-ML-8 with a malonate motif structure, is presented and discussed. After study, the small tracer that belongs to a member of ApoSense family is proved to be capable of imaging merely apoptotic regions in the CTX treated tumor-bearing mice. The experimental result is further confirmed by in vitro cell binding assays and TUNEL staining assay. As a result, (18)F-ML-8 could be used for noninvasive visualization of apoptosis induced by antitumor chemotherapy.

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