Molecular PET Imaging of Cyclophosphamide Induced Apoptosis with (18)F-ML-8

In this paper, a novel small-molecular apoptotic PET imaging probe, (18)F-ML-8 with a malonate motif structure, is presented and discussed. After study, the small tracer that belongs to a member of ApoSense family is proved to be capable of imaging merely apoptotic regions in the CTX treated tumor-b...

Descripción completa

Detalles Bibliográficos
Autores principales: Yao, Shaobo, Hu, Kongzhen, Tang, Ganghua, Gao, Siyuan, Tang, Caihua, Yao, Baoguo, Nie, Dahong, Sun, Ting, Jiang, Shende
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420799/
https://www.ncbi.nlm.nih.gov/pubmed/25977920
http://dx.doi.org/10.1155/2015/317403
_version_ 1782369763763159040
author Yao, Shaobo
Hu, Kongzhen
Tang, Ganghua
Gao, Siyuan
Tang, Caihua
Yao, Baoguo
Nie, Dahong
Sun, Ting
Jiang, Shende
author_facet Yao, Shaobo
Hu, Kongzhen
Tang, Ganghua
Gao, Siyuan
Tang, Caihua
Yao, Baoguo
Nie, Dahong
Sun, Ting
Jiang, Shende
author_sort Yao, Shaobo
collection PubMed
description In this paper, a novel small-molecular apoptotic PET imaging probe, (18)F-ML-8 with a malonate motif structure, is presented and discussed. After study, the small tracer that belongs to a member of ApoSense family is proved to be capable of imaging merely apoptotic regions in the CTX treated tumor-bearing mice. The experimental result is further confirmed by in vitro cell binding assays and TUNEL staining assay. As a result, (18)F-ML-8 could be used for noninvasive visualization of apoptosis induced by antitumor chemotherapy.
format Online
Article
Text
id pubmed-4420799
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-44207992015-05-14 Molecular PET Imaging of Cyclophosphamide Induced Apoptosis with (18)F-ML-8 Yao, Shaobo Hu, Kongzhen Tang, Ganghua Gao, Siyuan Tang, Caihua Yao, Baoguo Nie, Dahong Sun, Ting Jiang, Shende Biomed Res Int Research Article In this paper, a novel small-molecular apoptotic PET imaging probe, (18)F-ML-8 with a malonate motif structure, is presented and discussed. After study, the small tracer that belongs to a member of ApoSense family is proved to be capable of imaging merely apoptotic regions in the CTX treated tumor-bearing mice. The experimental result is further confirmed by in vitro cell binding assays and TUNEL staining assay. As a result, (18)F-ML-8 could be used for noninvasive visualization of apoptosis induced by antitumor chemotherapy. Hindawi Publishing Corporation 2015 2015-04-09 /pmc/articles/PMC4420799/ /pubmed/25977920 http://dx.doi.org/10.1155/2015/317403 Text en Copyright © 2015 Shaobo Yao et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yao, Shaobo
Hu, Kongzhen
Tang, Ganghua
Gao, Siyuan
Tang, Caihua
Yao, Baoguo
Nie, Dahong
Sun, Ting
Jiang, Shende
Molecular PET Imaging of Cyclophosphamide Induced Apoptosis with (18)F-ML-8
title Molecular PET Imaging of Cyclophosphamide Induced Apoptosis with (18)F-ML-8
title_full Molecular PET Imaging of Cyclophosphamide Induced Apoptosis with (18)F-ML-8
title_fullStr Molecular PET Imaging of Cyclophosphamide Induced Apoptosis with (18)F-ML-8
title_full_unstemmed Molecular PET Imaging of Cyclophosphamide Induced Apoptosis with (18)F-ML-8
title_short Molecular PET Imaging of Cyclophosphamide Induced Apoptosis with (18)F-ML-8
title_sort molecular pet imaging of cyclophosphamide induced apoptosis with (18)f-ml-8
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420799/
https://www.ncbi.nlm.nih.gov/pubmed/25977920
http://dx.doi.org/10.1155/2015/317403
work_keys_str_mv AT yaoshaobo molecularpetimagingofcyclophosphamideinducedapoptosiswith18fml8
AT hukongzhen molecularpetimagingofcyclophosphamideinducedapoptosiswith18fml8
AT tangganghua molecularpetimagingofcyclophosphamideinducedapoptosiswith18fml8
AT gaosiyuan molecularpetimagingofcyclophosphamideinducedapoptosiswith18fml8
AT tangcaihua molecularpetimagingofcyclophosphamideinducedapoptosiswith18fml8
AT yaobaoguo molecularpetimagingofcyclophosphamideinducedapoptosiswith18fml8
AT niedahong molecularpetimagingofcyclophosphamideinducedapoptosiswith18fml8
AT sunting molecularpetimagingofcyclophosphamideinducedapoptosiswith18fml8
AT jiangshende molecularpetimagingofcyclophosphamideinducedapoptosiswith18fml8

Ejemplares similares