Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding

Highly polymorphic major histocompatibility complex (MHC) molecules are at the heart of adaptive immune responses, playing crucial roles in many kinds of disease and in vaccination. We report that breadth of peptide presentation and level of cell surface expression of class I molecules are inversely...

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Detalles Bibliográficos
Autores principales: Chappell, Paul E, Meziane, El Kahina, Harrison, Michael, Magiera, Łukasz, Hermann, Clemens, Mears, Laura, Wrobel, Antoni G, Durant, Charlotte, Nielsen, Lise Lotte, Buus, Søren, Ternette, Nicola, Mwangi, William, Butter, Colin, Nair, Venugopal, Ahyee, Trudy, Duggleby, Richard, Madrigal, Alejandro, Roversi, Pietro, Lea, Susan M, Kaufman, Jim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420994/
https://www.ncbi.nlm.nih.gov/pubmed/25860507
http://dx.doi.org/10.7554/eLife.05345

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