Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity

OBJECTIVE: Adipose tissue is the primary site for lipid deposition that protects the organisms in cases of nutrient excess during obesogenic diets. The histone deacetylase Sirtuin 1 (SIRT1) inhibits adipocyte differentiation by targeting the transcription factor peroxisome proliferator activated-rec...

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Detalles Bibliográficos
Autores principales: Mayoral, Rafael, Osborn, Olivia, McNelis, Joanne, Johnson, Andrew M., Oh, Da Young, Izquierdo, Cristina Llorente, Chung, Heekyung, Li, Pingping, Traves, Paqui G., Bandyopadhyay, Gautam, Pessentheiner, Ariane R., Ofrecio, Jachelle M., Cook, Joshua R., Qiang, Li, Accili, Domenico, Olefsky, Jerrold M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421024/
https://www.ncbi.nlm.nih.gov/pubmed/25973386
http://dx.doi.org/10.1016/j.molmet.2015.02.007

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