Transcriptional Regulation of CYP3A4/2B6/2C9 Mediated via Nuclear Receptor PXR by Helicid and Its Metabolites

Objective. This study aims at establishing and validating an in vitro system to screen drug inducers of CYPs mediated via hPXR, as well as studying transcriptional regulation of CYPs mediated via hPXR by helicid and its two metabolites. Methods. Cloning the nuclear receptor hPXR and the promoters of...

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Detalles Bibliográficos
Autores principales: Chen, Qun, Xie, Hai-tang, Li, Yan, Wang, Guo, Xu, Zhe, Pu, Zhi-chen, Hu, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421101/
https://www.ncbi.nlm.nih.gov/pubmed/25977700
http://dx.doi.org/10.1155/2015/797496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421101/
https://www.ncbi.nlm.nih.gov/pubmed/25977700
http://dx.doi.org/10.1155/2015/797496

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