Acute myeloid leukemia in a patient with constitutional 47,XXY karyotype

Klinefelter syndrome (KS), a 47,XXY chromosomal abnormality, has been shown to be associated with a number of malignancies, but has not been linked to acute leukemias to date. We present a case of a 54-year-old male diagnosed with acute myeloid leukemia (AML) with monocytic differentiation, whose cy...

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Autores principales: Jalbut, Marla M., Sohani, Aliyah R., Cin, Paola Dal, Hasserjian, Robert P., Moran, Jenna A., Brunner, Andrew M., Fathi, Amir T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421110/
https://www.ncbi.nlm.nih.gov/pubmed/25973391
http://dx.doi.org/10.1016/j.lrr.2015.04.001
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author Jalbut, Marla M.
Sohani, Aliyah R.
Cin, Paola Dal
Hasserjian, Robert P.
Moran, Jenna A.
Brunner, Andrew M.
Fathi, Amir T.
author_facet Jalbut, Marla M.
Sohani, Aliyah R.
Cin, Paola Dal
Hasserjian, Robert P.
Moran, Jenna A.
Brunner, Andrew M.
Fathi, Amir T.
author_sort Jalbut, Marla M.
collection PubMed
description Klinefelter syndrome (KS), a 47,XXY chromosomal abnormality, has been shown to be associated with a number of malignancies, but has not been linked to acute leukemias to date. We present a case of a 54-year-old male diagnosed with acute myeloid leukemia (AML) with monocytic differentiation, whose cytogenetic and subsequent FISH analyses revealed a constitutional 47,XXY karyotype. We also review and discuss relevant prior literature.
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spelling pubmed-44211102015-05-13 Acute myeloid leukemia in a patient with constitutional 47,XXY karyotype Jalbut, Marla M. Sohani, Aliyah R. Cin, Paola Dal Hasserjian, Robert P. Moran, Jenna A. Brunner, Andrew M. Fathi, Amir T. Leuk Res Rep Article Klinefelter syndrome (KS), a 47,XXY chromosomal abnormality, has been shown to be associated with a number of malignancies, but has not been linked to acute leukemias to date. We present a case of a 54-year-old male diagnosed with acute myeloid leukemia (AML) with monocytic differentiation, whose cytogenetic and subsequent FISH analyses revealed a constitutional 47,XXY karyotype. We also review and discuss relevant prior literature. Elsevier 2015-04-22 /pmc/articles/PMC4421110/ /pubmed/25973391 http://dx.doi.org/10.1016/j.lrr.2015.04.001 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Jalbut, Marla M.
Sohani, Aliyah R.
Cin, Paola Dal
Hasserjian, Robert P.
Moran, Jenna A.
Brunner, Andrew M.
Fathi, Amir T.
Acute myeloid leukemia in a patient with constitutional 47,XXY karyotype
title Acute myeloid leukemia in a patient with constitutional 47,XXY karyotype
title_full Acute myeloid leukemia in a patient with constitutional 47,XXY karyotype
title_fullStr Acute myeloid leukemia in a patient with constitutional 47,XXY karyotype
title_full_unstemmed Acute myeloid leukemia in a patient with constitutional 47,XXY karyotype
title_short Acute myeloid leukemia in a patient with constitutional 47,XXY karyotype
title_sort acute myeloid leukemia in a patient with constitutional 47,xxy karyotype
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421110/
https://www.ncbi.nlm.nih.gov/pubmed/25973391
http://dx.doi.org/10.1016/j.lrr.2015.04.001
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