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Cellular changes following direct vitamin D injection into the uraemia-induced hyperplastic parathyroid gland

Background. Hyperplasia of the parathyroid gland (PTG) is associated not only with excessive secretion of parathyroid hormone (PTH) but also with changes in the parathyroid cell (PTC) characteristics (i.e. hyperproliferative activity and low contents of vitamin D and calcium-sensing receptors). The...

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Autores principales: Shiizaki, Kazuhiro, Hatamura, Ikuji, Negi, Shigeo, Nakazawa, Eiko, Tozawa, Ryoko, Izawa, Sayoko, Akizawa, Tadao, Kusano, Eiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421129/
https://www.ncbi.nlm.nih.gov/pubmed/25983973
http://dx.doi.org/10.1093/ndtplus/sfn095
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author Shiizaki, Kazuhiro
Hatamura, Ikuji
Negi, Shigeo
Nakazawa, Eiko
Tozawa, Ryoko
Izawa, Sayoko
Akizawa, Tadao
Kusano, Eiji
author_facet Shiizaki, Kazuhiro
Hatamura, Ikuji
Negi, Shigeo
Nakazawa, Eiko
Tozawa, Ryoko
Izawa, Sayoko
Akizawa, Tadao
Kusano, Eiji
author_sort Shiizaki, Kazuhiro
collection PubMed
description Background. Hyperplasia of the parathyroid gland (PTG) is associated not only with excessive secretion of parathyroid hormone (PTH) but also with changes in the parathyroid cell (PTC) characteristics (i.e. hyperproliferative activity and low contents of vitamin D and calcium-sensing receptors). The control of PTG hyperplasia is most important in the management of secondary hyperparathyroidism (SHPT), because the advanced stage of hyperplasia is considered irreversible. For the better control of the PTH level in dialysis patients with such advanced SHPT, percutaneous vitamin D injection therapy (PDIT) under ultrasonographic guidance was developed and various cellular changes caused by this treatment were also investigated using an animal model. Methods. The PTGs of Sprague–Dawley rats, which had been 5/6-nephrectomized and fed a high-phosphate diet, were treated with the direct injections of vitamin D agents, and cellular effects focusing the above-mentioned characters were investigated. Results. An adequacy of the direct injection technique into the rats’ PTGs and the successful effects of this treatment in various biochemical parameters were confirmed. Such characteristics of advanced SHPT were simultaneously improved; in particular, it was confirmed that this treatment may be effective in controlling PTG hyperplasia by, at least in part, apoptosis-induced cell death. Conclusions. A locally high level of vitamin D strongly may suppress PTH secretion and regress hyperplasia, which is involved in the induction of apoptosis in PTCs, based on the simultaneous improvements of cellular characters of advanced SHPT. The PTH control introduced by this treatment successfully ameliorated osteitis fibrosa (high bone turnover rate).
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spelling pubmed-44211292015-05-15 Cellular changes following direct vitamin D injection into the uraemia-induced hyperplastic parathyroid gland Shiizaki, Kazuhiro Hatamura, Ikuji Negi, Shigeo Nakazawa, Eiko Tozawa, Ryoko Izawa, Sayoko Akizawa, Tadao Kusano, Eiji NDT Plus Original Article Background. Hyperplasia of the parathyroid gland (PTG) is associated not only with excessive secretion of parathyroid hormone (PTH) but also with changes in the parathyroid cell (PTC) characteristics (i.e. hyperproliferative activity and low contents of vitamin D and calcium-sensing receptors). The control of PTG hyperplasia is most important in the management of secondary hyperparathyroidism (SHPT), because the advanced stage of hyperplasia is considered irreversible. For the better control of the PTH level in dialysis patients with such advanced SHPT, percutaneous vitamin D injection therapy (PDIT) under ultrasonographic guidance was developed and various cellular changes caused by this treatment were also investigated using an animal model. Methods. The PTGs of Sprague–Dawley rats, which had been 5/6-nephrectomized and fed a high-phosphate diet, were treated with the direct injections of vitamin D agents, and cellular effects focusing the above-mentioned characters were investigated. Results. An adequacy of the direct injection technique into the rats’ PTGs and the successful effects of this treatment in various biochemical parameters were confirmed. Such characteristics of advanced SHPT were simultaneously improved; in particular, it was confirmed that this treatment may be effective in controlling PTG hyperplasia by, at least in part, apoptosis-induced cell death. Conclusions. A locally high level of vitamin D strongly may suppress PTH secretion and regress hyperplasia, which is involved in the induction of apoptosis in PTCs, based on the simultaneous improvements of cellular characters of advanced SHPT. The PTH control introduced by this treatment successfully ameliorated osteitis fibrosa (high bone turnover rate). Oxford University Press 2008-08 /pmc/articles/PMC4421129/ /pubmed/25983973 http://dx.doi.org/10.1093/ndtplus/sfn095 Text en © The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Article
Shiizaki, Kazuhiro
Hatamura, Ikuji
Negi, Shigeo
Nakazawa, Eiko
Tozawa, Ryoko
Izawa, Sayoko
Akizawa, Tadao
Kusano, Eiji
Cellular changes following direct vitamin D injection into the uraemia-induced hyperplastic parathyroid gland
title Cellular changes following direct vitamin D injection into the uraemia-induced hyperplastic parathyroid gland
title_full Cellular changes following direct vitamin D injection into the uraemia-induced hyperplastic parathyroid gland
title_fullStr Cellular changes following direct vitamin D injection into the uraemia-induced hyperplastic parathyroid gland
title_full_unstemmed Cellular changes following direct vitamin D injection into the uraemia-induced hyperplastic parathyroid gland
title_short Cellular changes following direct vitamin D injection into the uraemia-induced hyperplastic parathyroid gland
title_sort cellular changes following direct vitamin d injection into the uraemia-induced hyperplastic parathyroid gland
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421129/
https://www.ncbi.nlm.nih.gov/pubmed/25983973
http://dx.doi.org/10.1093/ndtplus/sfn095
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