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Effects of reducing the lactate and glucose content of PD solutions on the peritoneum. Is the future GLAD?

Background. Long-term peritoneal dialysis (PD) may lead to functional and morphologic changes in the peritoneal membrane, probably because of the continuous exposure to conventional dialysis solutions. Methods. The morphologic changes include neoangiogenesis and fibrosis. The authors of this article...

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Autores principales: Krediet, Raymond T., Zweers, Machteld M., van Westrhenen, Roos, Zegwaard, Agnes, Struijk, Dirk G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421143/
https://www.ncbi.nlm.nih.gov/pubmed/25983988
http://dx.doi.org/10.1093/ndtplus/sfn126
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author Krediet, Raymond T.
Zweers, Machteld M.
van Westrhenen, Roos
Zegwaard, Agnes
Struijk, Dirk G.
author_facet Krediet, Raymond T.
Zweers, Machteld M.
van Westrhenen, Roos
Zegwaard, Agnes
Struijk, Dirk G.
author_sort Krediet, Raymond T.
collection PubMed
description Background. Long-term peritoneal dialysis (PD) may lead to functional and morphologic changes in the peritoneal membrane, probably because of the continuous exposure to conventional dialysis solutions. Methods. The morphologic changes include neoangiogenesis and fibrosis. The authors of this article developed a long-term peritoneal exposure model in rats, in which the morphological alterations could be induced after daily peritoneal infusion of a 3.86% glucose/lactate-buffered conventional PD solution. Results and Conclusions. In the present article, a review of the model and of the results obtained with various available and experimental solutions is given. It appeared that high lactate concentrations contributed to the glucose-induced neoangiogenesis by pseudohypoxia. Glucose degradation products were probably more important in the induction of peritoneal fibrosis. The promising results of a combination of amino acids, glycerol and glucose, each in a low concentration, buffered with either pyruvate or bicarbonate/lactate, are presented and discussed. The combination of glycerol, amino acids and dextrose, dissolved in a bicarbonate/lactate buffer (GLAD), may be an option for a new generation of dialysis fluids.
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spelling pubmed-44211432015-05-15 Effects of reducing the lactate and glucose content of PD solutions on the peritoneum. Is the future GLAD? Krediet, Raymond T. Zweers, Machteld M. van Westrhenen, Roos Zegwaard, Agnes Struijk, Dirk G. NDT Plus Original Articles Background. Long-term peritoneal dialysis (PD) may lead to functional and morphologic changes in the peritoneal membrane, probably because of the continuous exposure to conventional dialysis solutions. Methods. The morphologic changes include neoangiogenesis and fibrosis. The authors of this article developed a long-term peritoneal exposure model in rats, in which the morphological alterations could be induced after daily peritoneal infusion of a 3.86% glucose/lactate-buffered conventional PD solution. Results and Conclusions. In the present article, a review of the model and of the results obtained with various available and experimental solutions is given. It appeared that high lactate concentrations contributed to the glucose-induced neoangiogenesis by pseudohypoxia. Glucose degradation products were probably more important in the induction of peritoneal fibrosis. The promising results of a combination of amino acids, glycerol and glucose, each in a low concentration, buffered with either pyruvate or bicarbonate/lactate, are presented and discussed. The combination of glycerol, amino acids and dextrose, dissolved in a bicarbonate/lactate buffer (GLAD), may be an option for a new generation of dialysis fluids. Oxford University Press 2008-10 /pmc/articles/PMC4421143/ /pubmed/25983988 http://dx.doi.org/10.1093/ndtplus/sfn126 Text en © The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Articles
Krediet, Raymond T.
Zweers, Machteld M.
van Westrhenen, Roos
Zegwaard, Agnes
Struijk, Dirk G.
Effects of reducing the lactate and glucose content of PD solutions on the peritoneum. Is the future GLAD?
title Effects of reducing the lactate and glucose content of PD solutions on the peritoneum. Is the future GLAD?
title_full Effects of reducing the lactate and glucose content of PD solutions on the peritoneum. Is the future GLAD?
title_fullStr Effects of reducing the lactate and glucose content of PD solutions on the peritoneum. Is the future GLAD?
title_full_unstemmed Effects of reducing the lactate and glucose content of PD solutions on the peritoneum. Is the future GLAD?
title_short Effects of reducing the lactate and glucose content of PD solutions on the peritoneum. Is the future GLAD?
title_sort effects of reducing the lactate and glucose content of pd solutions on the peritoneum. is the future glad?
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421143/
https://www.ncbi.nlm.nih.gov/pubmed/25983988
http://dx.doi.org/10.1093/ndtplus/sfn126
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