High-grade urothelial carcinoma in a kidney transplant recipient with BK virus infection

Bladder malignancy in the kidney transplant recipient is rare and compared with the general population tends to be of high grade and have an aggressive clinical course. In this report, we describe a case of urothelial carcinoma developing in a kidney transplant recipient 6 years after the diagnosis...

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Autores principales: Hill, Prue, Slavin, John, Goodman, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421192/
https://www.ncbi.nlm.nih.gov/pubmed/25984002
http://dx.doi.org/10.1093/ndtplus/sfp025
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author Hill, Prue
Slavin, John
Goodman, David
author_facet Hill, Prue
Slavin, John
Goodman, David
author_sort Hill, Prue
collection PubMed
description Bladder malignancy in the kidney transplant recipient is rare and compared with the general population tends to be of high grade and have an aggressive clinical course. In this report, we describe a case of urothelial carcinoma developing in a kidney transplant recipient 6 years after the diagnosis of polyomavirus nephropathy (PVN). BK virus (BKV) DNA was identified in urine and serum by PCR. The diffuse strong staining of SV40 T-antigen and p53 within both the in situ and invasive carcinoma suggest that BKV may play a role in the oncogenic pathway in this clinical setting.
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spelling pubmed-44211922015-05-15 High-grade urothelial carcinoma in a kidney transplant recipient with BK virus infection Hill, Prue Slavin, John Goodman, David NDT Plus Case Report Bladder malignancy in the kidney transplant recipient is rare and compared with the general population tends to be of high grade and have an aggressive clinical course. In this report, we describe a case of urothelial carcinoma developing in a kidney transplant recipient 6 years after the diagnosis of polyomavirus nephropathy (PVN). BK virus (BKV) DNA was identified in urine and serum by PCR. The diffuse strong staining of SV40 T-antigen and p53 within both the in situ and invasive carcinoma suggest that BKV may play a role in the oncogenic pathway in this clinical setting. Oxford University Press 2009-06 2009-02-26 /pmc/articles/PMC4421192/ /pubmed/25984002 http://dx.doi.org/10.1093/ndtplus/sfp025 Text en © The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Hill, Prue
Slavin, John
Goodman, David
High-grade urothelial carcinoma in a kidney transplant recipient with BK virus infection
title High-grade urothelial carcinoma in a kidney transplant recipient with BK virus infection
title_full High-grade urothelial carcinoma in a kidney transplant recipient with BK virus infection
title_fullStr High-grade urothelial carcinoma in a kidney transplant recipient with BK virus infection
title_full_unstemmed High-grade urothelial carcinoma in a kidney transplant recipient with BK virus infection
title_short High-grade urothelial carcinoma in a kidney transplant recipient with BK virus infection
title_sort high-grade urothelial carcinoma in a kidney transplant recipient with bk virus infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421192/
https://www.ncbi.nlm.nih.gov/pubmed/25984002
http://dx.doi.org/10.1093/ndtplus/sfp025
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