Membranous nephropathy associated with gastrointestinal stromal tumour: a case report

Membranous nephropathy (MN) is a common cause of nephrotic syndrome in older adults. The association of MN with neoplasia has been controversial, but several recent studies have shown increase incidence of cancer in patients with MN [1]. We report a case of a 49-year-old male with severe nephrotic s...

Descripción completa

Detalles Bibliográficos
Autores principales: Cimic, Adela, Pastan, Stephen O., Bijol, Vanesa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421245/
https://www.ncbi.nlm.nih.gov/pubmed/25984023
http://dx.doi.org/10.1093/ndtplus/sfp028
_version_ 1782369825039843328
author Cimic, Adela
Pastan, Stephen O.
Bijol, Vanesa
author_facet Cimic, Adela
Pastan, Stephen O.
Bijol, Vanesa
author_sort Cimic, Adela
collection PubMed
description Membranous nephropathy (MN) is a common cause of nephrotic syndrome in older adults. The association of MN with neoplasia has been controversial, but several recent studies have shown increase incidence of cancer in patients with MN [1]. We report a case of a 49-year-old male with severe nephrotic syndrome and concomitant jejunal gastrointestinal stromal tumour (GIST). The combination of preoperative Imatinib mesylate chemotherapy and tumour excision was followed by complete resolution of proteinuria within 19 months, without specific treatment for MN. An association between MN and GIST has never previously been reported in the literature.
format Online
Article
Text
id pubmed-4421245
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-44212452015-05-15 Membranous nephropathy associated with gastrointestinal stromal tumour: a case report Cimic, Adela Pastan, Stephen O. Bijol, Vanesa NDT Plus Case Report Membranous nephropathy (MN) is a common cause of nephrotic syndrome in older adults. The association of MN with neoplasia has been controversial, but several recent studies have shown increase incidence of cancer in patients with MN [1]. We report a case of a 49-year-old male with severe nephrotic syndrome and concomitant jejunal gastrointestinal stromal tumour (GIST). The combination of preoperative Imatinib mesylate chemotherapy and tumour excision was followed by complete resolution of proteinuria within 19 months, without specific treatment for MN. An association between MN and GIST has never previously been reported in the literature. Oxford University Press 2009-08 2009-03-04 /pmc/articles/PMC4421245/ /pubmed/25984023 http://dx.doi.org/10.1093/ndtplus/sfp028 Text en © The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Cimic, Adela
Pastan, Stephen O.
Bijol, Vanesa
Membranous nephropathy associated with gastrointestinal stromal tumour: a case report
title Membranous nephropathy associated with gastrointestinal stromal tumour: a case report
title_full Membranous nephropathy associated with gastrointestinal stromal tumour: a case report
title_fullStr Membranous nephropathy associated with gastrointestinal stromal tumour: a case report
title_full_unstemmed Membranous nephropathy associated with gastrointestinal stromal tumour: a case report
title_short Membranous nephropathy associated with gastrointestinal stromal tumour: a case report
title_sort membranous nephropathy associated with gastrointestinal stromal tumour: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421245/
https://www.ncbi.nlm.nih.gov/pubmed/25984023
http://dx.doi.org/10.1093/ndtplus/sfp028
work_keys_str_mv AT cimicadela membranousnephropathyassociatedwithgastrointestinalstromaltumouracasereport
AT pastanstepheno membranousnephropathyassociatedwithgastrointestinalstromaltumouracasereport
AT bijolvanesa membranousnephropathyassociatedwithgastrointestinalstromaltumouracasereport

Ejemplares similares