Overcoming antigen masking of anti-amyloidbeta antibodies reveals breaking of B cell tolerance by virus-like particles in amyloidbeta immunized amyloid precursor protein transgenic mice

BACKGROUND: In prior work we detected reduced anti-Aβ antibody titers in Aβ-vaccinated transgenic mice expressing the human amyloid precursor protein (APP) compared to nontransgenic littermates. We investigated this observation further by vaccinating APP and nontransgenic mice with either the wild-t...

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Detalles Bibliográficos
Autores principales: Li, Qingyou, Cao, Chuanhai, Chackerian, Bryce, Schiller, John, Gordon, Marcia, Ugen, Kenneth E, Morgan, Dave
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC442125/
https://www.ncbi.nlm.nih.gov/pubmed/15186505
http://dx.doi.org/10.1186/1471-2202-5-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC442125/
https://www.ncbi.nlm.nih.gov/pubmed/15186505
http://dx.doi.org/10.1186/1471-2202-5-21

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