Acetazolamide may provoke cyclosporine toxicity—a case report

We describe a 58-year-old female renal transplantant recipient with standard cyclosporine-based immunosuppression who developed a potentially toxic cyclosporine concentration of 265 ng/ml after having started acetazolamide for severe glaucoma. The mechanism explaining the interaction between acetazo...

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Detalles Bibliográficos
Autores principales: Ruokoniemi, Päivi, Tertti, Risto, Paalosmaa-Puusa, Pia, Kareranta, Hannele, Laine, Kari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421251/
https://www.ncbi.nlm.nih.gov/pubmed/25984020
http://dx.doi.org/10.1093/ndtplus/sfp046
Descripción
Sumario:We describe a 58-year-old female renal transplantant recipient with standard cyclosporine-based immunosuppression who developed a potentially toxic cyclosporine concentration of 265 ng/ml after having started acetazolamide for severe glaucoma. The mechanism explaining the interaction between acetazolamide and cyclosporine remains unknown, but the concomitant use of these agents is not uncommon. The follow-up of cyclosporine concentrations is necessary, and the reduction of the cyclosporine dose is likely to be needed when patients taking cyclosporine are started with acetazolamide.

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