Acetazolamide may provoke cyclosporine toxicity—a case report

We describe a 58-year-old female renal transplantant recipient with standard cyclosporine-based immunosuppression who developed a potentially toxic cyclosporine concentration of 265 ng/ml after having started acetazolamide for severe glaucoma. The mechanism explaining the interaction between acetazo...

Descripción completa

Detalles Bibliográficos
Autores principales: Ruokoniemi, Päivi, Tertti, Risto, Paalosmaa-Puusa, Pia, Kareranta, Hannele, Laine, Kari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421251/
https://www.ncbi.nlm.nih.gov/pubmed/25984020
http://dx.doi.org/10.1093/ndtplus/sfp046
_version_ 1782369826495266816
author Ruokoniemi, Päivi
Tertti, Risto
Paalosmaa-Puusa, Pia
Kareranta, Hannele
Laine, Kari
author_facet Ruokoniemi, Päivi
Tertti, Risto
Paalosmaa-Puusa, Pia
Kareranta, Hannele
Laine, Kari
author_sort Ruokoniemi, Päivi
collection PubMed
description We describe a 58-year-old female renal transplantant recipient with standard cyclosporine-based immunosuppression who developed a potentially toxic cyclosporine concentration of 265 ng/ml after having started acetazolamide for severe glaucoma. The mechanism explaining the interaction between acetazolamide and cyclosporine remains unknown, but the concomitant use of these agents is not uncommon. The follow-up of cyclosporine concentrations is necessary, and the reduction of the cyclosporine dose is likely to be needed when patients taking cyclosporine are started with acetazolamide.
format Online
Article
Text
id pubmed-4421251
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-44212512015-05-15 Acetazolamide may provoke cyclosporine toxicity—a case report Ruokoniemi, Päivi Tertti, Risto Paalosmaa-Puusa, Pia Kareranta, Hannele Laine, Kari NDT Plus Case Report We describe a 58-year-old female renal transplantant recipient with standard cyclosporine-based immunosuppression who developed a potentially toxic cyclosporine concentration of 265 ng/ml after having started acetazolamide for severe glaucoma. The mechanism explaining the interaction between acetazolamide and cyclosporine remains unknown, but the concomitant use of these agents is not uncommon. The follow-up of cyclosporine concentrations is necessary, and the reduction of the cyclosporine dose is likely to be needed when patients taking cyclosporine are started with acetazolamide. Oxford University Press 2009-08 2009-04-22 /pmc/articles/PMC4421251/ /pubmed/25984020 http://dx.doi.org/10.1093/ndtplus/sfp046 Text en © The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Ruokoniemi, Päivi
Tertti, Risto
Paalosmaa-Puusa, Pia
Kareranta, Hannele
Laine, Kari
Acetazolamide may provoke cyclosporine toxicity—a case report
title Acetazolamide may provoke cyclosporine toxicity—a case report
title_full Acetazolamide may provoke cyclosporine toxicity—a case report
title_fullStr Acetazolamide may provoke cyclosporine toxicity—a case report
title_full_unstemmed Acetazolamide may provoke cyclosporine toxicity—a case report
title_short Acetazolamide may provoke cyclosporine toxicity—a case report
title_sort acetazolamide may provoke cyclosporine toxicity—a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421251/
https://www.ncbi.nlm.nih.gov/pubmed/25984020
http://dx.doi.org/10.1093/ndtplus/sfp046
work_keys_str_mv AT ruokoniemipaivi acetazolamidemayprovokecyclosporinetoxicityacasereport
AT terttiristo acetazolamidemayprovokecyclosporinetoxicityacasereport
AT paalosmaapuusapia acetazolamidemayprovokecyclosporinetoxicityacasereport
AT karerantahannele acetazolamidemayprovokecyclosporinetoxicityacasereport
AT lainekari acetazolamidemayprovokecyclosporinetoxicityacasereport

Ejemplares similares