Severe adverse effects of 5-fluorouracil in S-1 were lessened by haemodialysis due to elimination of the drug

S-1 and cisplatin are used as one of the first-line chemotherapies for gastric cancer in Japan. The plasma concentration of 5-fluorouracil (5-FU) is increased in patients with renal dysfunction because gimeracil in S-1 inhibits the degradation of 5-FU and about 50% of gimeracil is excreted in the ur...

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Autores principales: Inoue, Kazunori, Nagasawa, Yasuyuki, Yamamoto, Ryohei, Omori, Hiroki, Kimura, Tomonori, Tomida, Kodo, Furumatsu, Yoshiyuki, Imai, Enyu, Isaka, Yoshitaka, Rakugi, Hiromi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421365/
https://www.ncbi.nlm.nih.gov/pubmed/25949315
http://dx.doi.org/10.1093/ndtplus/sfn195
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author Inoue, Kazunori
Nagasawa, Yasuyuki
Yamamoto, Ryohei
Omori, Hiroki
Kimura, Tomonori
Tomida, Kodo
Furumatsu, Yoshiyuki
Imai, Enyu
Isaka, Yoshitaka
Rakugi, Hiromi
author_facet Inoue, Kazunori
Nagasawa, Yasuyuki
Yamamoto, Ryohei
Omori, Hiroki
Kimura, Tomonori
Tomida, Kodo
Furumatsu, Yoshiyuki
Imai, Enyu
Isaka, Yoshitaka
Rakugi, Hiromi
author_sort Inoue, Kazunori
collection PubMed
description S-1 and cisplatin are used as one of the first-line chemotherapies for gastric cancer in Japan. The plasma concentration of 5-fluorouracil (5-FU) is increased in patients with renal dysfunction because gimeracil in S-1 inhibits the degradation of 5-FU and about 50% of gimeracil is excreted in the urine. We describe a 35-year-old man with acute kidney injury while taking S-1 and cisplatin for advanced gastric cancer and who presented severe adverse effects of 5-FU. This case report describes the evolution of the plasma concentrations of 5-FU with haemodialysis along with a decrease in the adverse drug effects.
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spelling pubmed-44213652015-05-06 Severe adverse effects of 5-fluorouracil in S-1 were lessened by haemodialysis due to elimination of the drug Inoue, Kazunori Nagasawa, Yasuyuki Yamamoto, Ryohei Omori, Hiroki Kimura, Tomonori Tomida, Kodo Furumatsu, Yoshiyuki Imai, Enyu Isaka, Yoshitaka Rakugi, Hiromi NDT Plus Case Report S-1 and cisplatin are used as one of the first-line chemotherapies for gastric cancer in Japan. The plasma concentration of 5-fluorouracil (5-FU) is increased in patients with renal dysfunction because gimeracil in S-1 inhibits the degradation of 5-FU and about 50% of gimeracil is excreted in the urine. We describe a 35-year-old man with acute kidney injury while taking S-1 and cisplatin for advanced gastric cancer and who presented severe adverse effects of 5-FU. This case report describes the evolution of the plasma concentrations of 5-FU with haemodialysis along with a decrease in the adverse drug effects. Oxford University Press 2009-04 2008-12-18 /pmc/articles/PMC4421365/ /pubmed/25949315 http://dx.doi.org/10.1093/ndtplus/sfn195 Text en © The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Inoue, Kazunori
Nagasawa, Yasuyuki
Yamamoto, Ryohei
Omori, Hiroki
Kimura, Tomonori
Tomida, Kodo
Furumatsu, Yoshiyuki
Imai, Enyu
Isaka, Yoshitaka
Rakugi, Hiromi
Severe adverse effects of 5-fluorouracil in S-1 were lessened by haemodialysis due to elimination of the drug
title Severe adverse effects of 5-fluorouracil in S-1 were lessened by haemodialysis due to elimination of the drug
title_full Severe adverse effects of 5-fluorouracil in S-1 were lessened by haemodialysis due to elimination of the drug
title_fullStr Severe adverse effects of 5-fluorouracil in S-1 were lessened by haemodialysis due to elimination of the drug
title_full_unstemmed Severe adverse effects of 5-fluorouracil in S-1 were lessened by haemodialysis due to elimination of the drug
title_short Severe adverse effects of 5-fluorouracil in S-1 were lessened by haemodialysis due to elimination of the drug
title_sort severe adverse effects of 5-fluorouracil in s-1 were lessened by haemodialysis due to elimination of the drug
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421365/
https://www.ncbi.nlm.nih.gov/pubmed/25949315
http://dx.doi.org/10.1093/ndtplus/sfn195
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