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Severe adverse effects of 5-fluorouracil in S-1 were lessened by haemodialysis due to elimination of the drug
S-1 and cisplatin are used as one of the first-line chemotherapies for gastric cancer in Japan. The plasma concentration of 5-fluorouracil (5-FU) is increased in patients with renal dysfunction because gimeracil in S-1 inhibits the degradation of 5-FU and about 50% of gimeracil is excreted in the ur...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421365/ https://www.ncbi.nlm.nih.gov/pubmed/25949315 http://dx.doi.org/10.1093/ndtplus/sfn195 |