Renal biopsy in a patient with haemophilia A and cryoglobulinaemic membranoproliferative glomerulonephritis associated with hepatitis C virus infection

A renal biopsy was performed in a 47-year-old man with haemophilia A. Thirty minutes after administration of an intravenous bolus of 4000 units of recombinant factor VIII, which increased the activity to 74–91%, a needle renal biopsy was successfully performed, followed by administration of 3000 uni...

Descripción completa

Detalles Bibliográficos
Autores principales: Kobayashi, Ikue, Ishimura, Eiji, Hirowatari, Kaname, Tsuchida, Takao, Nishihira, Ayako, Shima, Hideaki, Shidara, Kaori, Mori, Katsuhito, Inaba, Masaaki, Wakasa, Ken-ichi, Nishizawa, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421390/
https://www.ncbi.nlm.nih.gov/pubmed/25949347
http://dx.doi.org/10.1093/ndtplus/sfp072
Descripción
Sumario:A renal biopsy was performed in a 47-year-old man with haemophilia A. Thirty minutes after administration of an intravenous bolus of 4000 units of recombinant factor VIII, which increased the activity to 74–91%, a needle renal biopsy was successfully performed, followed by administration of 3000 units of factor VIII in the evening, and then the subsequent morning and evening. The patient was diagnosed with hepatitis C virus-associated membranoproliferative glomerulonephritis. Treatment with interferon, ribavirin, prednisolone and cyclosporine A improved the nephrotic syndrome. This is the first report of a successful renal biopsy in a patient with haemophilia A after factor VIII injection.

Ejemplares similares