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Inadequate drug prescription and the rise in drug-induced acute tubulointerstitial nephritis incidence

Drugs are a frequent cause of acute tubulointerstitial nephritis (ATIN). Antibiotics, non-steroidal anti-inflammatory drugs and recently proton pump inhibitors stand among the most commonly responsible ones. However, their respective responsibility is not well known. This study reports 33 cases of d...

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Detalles Bibliográficos
Autores principales: Garcia, Montserrat, Saracho, Ramón, Jaio, Nekane, Vrotsoukanari, Kalliopi, Aguirre, Carmelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421411/
https://www.ncbi.nlm.nih.gov/pubmed/25949466
http://dx.doi.org/10.1093/ndtplus/sfq146
Descripción
Sumario:Drugs are a frequent cause of acute tubulointerstitial nephritis (ATIN). Antibiotics, non-steroidal anti-inflammatory drugs and recently proton pump inhibitors stand among the most commonly responsible ones. However, their respective responsibility is not well known. This study reports 33 cases of drug-induced ATIN (DI-ATIN), the most frequent ones being metamizole and omeprazole. Clinicians often fail to diagnose DI-ATIN because its signs and symptoms are non-specific and differ from the now classic form observed with methicillin. Furthermore, drugs causing ATIN are too often prescribed unnecessarily. This study shows that in more than one-fifth of our cases, ATIN complicated prescription of a drug that was not justified by an adequate clinical indication. The consequences were noxious for the patients and costly in terms of public health expenses.