Successful kidney transplantation with a well-matched donor despite a positive crossmatch; detection and management of sensitization secondary to an alternate allelic variant of ‘self’ HLA

Under current UK standards of deceased donor typing, the formation by the recipient of HLA antibody against an allelic variant of a ‘self’ antigen creates a particular problem for organ allocation. In the reported case, the decision to transplant was taken in the situation of a positive flow crossma...

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Detalles Bibliográficos
Autores principales: Clark, Brendan, Marsden, Neil, McKinley, Katherine, Lewington, Andrew, Newstead, Chas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
II. Clinical Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421440/
https://www.ncbi.nlm.nih.gov/pubmed/25949497
http://dx.doi.org/10.1093/ndtplus/sfr048
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author Clark, Brendan
Marsden, Neil
McKinley, Katherine
Lewington, Andrew
Newstead, Chas
author_facet Clark, Brendan
Marsden, Neil
McKinley, Katherine
Lewington, Andrew
Newstead, Chas
author_sort Clark, Brendan
collection PubMed
description Under current UK standards of deceased donor typing, the formation by the recipient of HLA antibody against an allelic variant of a ‘self’ antigen creates a particular problem for organ allocation. In the reported case, the decision to transplant was taken in the situation of a positive flow crossmatch result attributed to allelic antibody. The potential that target antigen density contributed to this patient’s subsequent good outcome is discussed.
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spelling pubmed-44214402015-05-06 Successful kidney transplantation with a well-matched donor despite a positive crossmatch; detection and management of sensitization secondary to an alternate allelic variant of ‘self’ HLA Clark, Brendan Marsden, Neil McKinley, Katherine Lewington, Andrew Newstead, Chas NDT Plus II. Clinical Reports Under current UK standards of deceased donor typing, the formation by the recipient of HLA antibody against an allelic variant of a ‘self’ antigen creates a particular problem for organ allocation. In the reported case, the decision to transplant was taken in the situation of a positive flow crossmatch result attributed to allelic antibody. The potential that target antigen density contributed to this patient’s subsequent good outcome is discussed. Oxford University Press 2011-08 2011-04-27 /pmc/articles/PMC4421440/ /pubmed/25949497 http://dx.doi.org/10.1093/ndtplus/sfr048 Text en © The Author 2011. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle II. Clinical Reports
Clark, Brendan
Marsden, Neil
McKinley, Katherine
Lewington, Andrew
Newstead, Chas
Successful kidney transplantation with a well-matched donor despite a positive crossmatch; detection and management of sensitization secondary to an alternate allelic variant of ‘self’ HLA
title Successful kidney transplantation with a well-matched donor despite a positive crossmatch; detection and management of sensitization secondary to an alternate allelic variant of ‘self’ HLA
title_full Successful kidney transplantation with a well-matched donor despite a positive crossmatch; detection and management of sensitization secondary to an alternate allelic variant of ‘self’ HLA
title_fullStr Successful kidney transplantation with a well-matched donor despite a positive crossmatch; detection and management of sensitization secondary to an alternate allelic variant of ‘self’ HLA
title_full_unstemmed Successful kidney transplantation with a well-matched donor despite a positive crossmatch; detection and management of sensitization secondary to an alternate allelic variant of ‘self’ HLA
title_short Successful kidney transplantation with a well-matched donor despite a positive crossmatch; detection and management of sensitization secondary to an alternate allelic variant of ‘self’ HLA
title_sort successful kidney transplantation with a well-matched donor despite a positive crossmatch; detection and management of sensitization secondary to an alternate allelic variant of ‘self’ hla
topic II. Clinical Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421440/
https://www.ncbi.nlm.nih.gov/pubmed/25949497
http://dx.doi.org/10.1093/ndtplus/sfr048
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