Post-transplant lymphoproliferative disorder: case report and review of susceptibility to EBV in the Scottish adult renal transplant pool

We report a case of high-grade non-Hodgkin's lymphoma following Epstein-Barr virus (EBV) infection in a 38-year-old renal transplant recipient who was successfully treated with rituximab and remains alive 6 years later with reasonable graft function. We subsequently undertook a survey showing t...

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Detalles Bibliográficos
Autores principales: Selvarajah, Viknesh, Lake, Katie, Robertson, Sue, Carman, William, Isles, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421486/
https://www.ncbi.nlm.nih.gov/pubmed/25949287
http://dx.doi.org/10.1093/ndtplus/sfn180
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author Selvarajah, Viknesh
Lake, Katie
Robertson, Sue
Carman, William
Isles, Chris
author_facet Selvarajah, Viknesh
Lake, Katie
Robertson, Sue
Carman, William
Isles, Chris
author_sort Selvarajah, Viknesh
collection PubMed
description We report a case of high-grade non-Hodgkin's lymphoma following Epstein-Barr virus (EBV) infection in a 38-year-old renal transplant recipient who was successfully treated with rituximab and remains alive 6 years later with reasonable graft function. We subsequently undertook a survey showing that 1.8% of the Scottish adult transplant pool are susceptible to EBV infection. Though a vaccine for EBV is currently not yet available, routine screening of potential renal transplant recipients for EBV should help identify those at increased risk of post-transplant lymhoproliferative disorder (PTLD), while tailoring of immunosuppression and antiviral prophylaxis with Ganciclovir may help reduce the emergence of this potentially life-threatening disease.
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spelling pubmed-44214862015-05-06 Post-transplant lymphoproliferative disorder: case report and review of susceptibility to EBV in the Scottish adult renal transplant pool Selvarajah, Viknesh Lake, Katie Robertson, Sue Carman, William Isles, Chris NDT Plus Case Report We report a case of high-grade non-Hodgkin's lymphoma following Epstein-Barr virus (EBV) infection in a 38-year-old renal transplant recipient who was successfully treated with rituximab and remains alive 6 years later with reasonable graft function. We subsequently undertook a survey showing that 1.8% of the Scottish adult transplant pool are susceptible to EBV infection. Though a vaccine for EBV is currently not yet available, routine screening of potential renal transplant recipients for EBV should help identify those at increased risk of post-transplant lymhoproliferative disorder (PTLD), while tailoring of immunosuppression and antiviral prophylaxis with Ganciclovir may help reduce the emergence of this potentially life-threatening disease. Oxford University Press 2009-02 2008-11-25 /pmc/articles/PMC4421486/ /pubmed/25949287 http://dx.doi.org/10.1093/ndtplus/sfn180 Text en © The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Selvarajah, Viknesh
Lake, Katie
Robertson, Sue
Carman, William
Isles, Chris
Post-transplant lymphoproliferative disorder: case report and review of susceptibility to EBV in the Scottish adult renal transplant pool
title Post-transplant lymphoproliferative disorder: case report and review of susceptibility to EBV in the Scottish adult renal transplant pool
title_full Post-transplant lymphoproliferative disorder: case report and review of susceptibility to EBV in the Scottish adult renal transplant pool
title_fullStr Post-transplant lymphoproliferative disorder: case report and review of susceptibility to EBV in the Scottish adult renal transplant pool
title_full_unstemmed Post-transplant lymphoproliferative disorder: case report and review of susceptibility to EBV in the Scottish adult renal transplant pool
title_short Post-transplant lymphoproliferative disorder: case report and review of susceptibility to EBV in the Scottish adult renal transplant pool
title_sort post-transplant lymphoproliferative disorder: case report and review of susceptibility to ebv in the scottish adult renal transplant pool
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421486/
https://www.ncbi.nlm.nih.gov/pubmed/25949287
http://dx.doi.org/10.1093/ndtplus/sfn180
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