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Adult-onset Still's disease associated with collapsing glomerulopathy
A young woman of African descent presented with fevers, arthralgia, lymphadenopathy and a skin rash. Modest proteinuria was also noted. The clinical picture suggested an acute HIV sero-conversion illness, and a renal biopsy showed a collapsing glomerulopathy compatible with that diagnosis. However,...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421551/ https://www.ncbi.nlm.nih.gov/pubmed/25949406 http://dx.doi.org/10.1093/ndtplus/sfp114 |
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author | Arulkumaran, Nishkantha Reitbock, Pablo Halliday, Kirsty Onwubalili, James Jayasena, Dakshina Dupont, Peter J. |
author_facet | Arulkumaran, Nishkantha Reitbock, Pablo Halliday, Kirsty Onwubalili, James Jayasena, Dakshina Dupont, Peter J. |
author_sort | Arulkumaran, Nishkantha |
collection | PubMed |
description | A young woman of African descent presented with fevers, arthralgia, lymphadenopathy and a skin rash. Modest proteinuria was also noted. The clinical picture suggested an acute HIV sero-conversion illness, and a renal biopsy showed a collapsing glomerulopathy compatible with that diagnosis. However, HIV serology proved persistently negative and a diagnosis of Adult Still's disease was subsequently made (by Yamaguchi criteria). Following steroid treatment, the patient's fever abated and her inflammatory markers returned to normal. Collapsing glomerulopathy is a rare but important complication of Adult Still's disease. Immunosuppressive treatment may be effective in improving renal outcome. |
format | Online Article Text |
id | pubmed-4421551 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-44215512015-05-06 Adult-onset Still's disease associated with collapsing glomerulopathy Arulkumaran, Nishkantha Reitbock, Pablo Halliday, Kirsty Onwubalili, James Jayasena, Dakshina Dupont, Peter J. NDT Plus Case Report A young woman of African descent presented with fevers, arthralgia, lymphadenopathy and a skin rash. Modest proteinuria was also noted. The clinical picture suggested an acute HIV sero-conversion illness, and a renal biopsy showed a collapsing glomerulopathy compatible with that diagnosis. However, HIV serology proved persistently negative and a diagnosis of Adult Still's disease was subsequently made (by Yamaguchi criteria). Following steroid treatment, the patient's fever abated and her inflammatory markers returned to normal. Collapsing glomerulopathy is a rare but important complication of Adult Still's disease. Immunosuppressive treatment may be effective in improving renal outcome. Oxford University Press 2010-02 2009-08-26 /pmc/articles/PMC4421551/ /pubmed/25949406 http://dx.doi.org/10.1093/ndtplus/sfp114 Text en © The Author 2009. Published by Oxford University Press [on behalf of ERA-EDTA]. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Case Report Arulkumaran, Nishkantha Reitbock, Pablo Halliday, Kirsty Onwubalili, James Jayasena, Dakshina Dupont, Peter J. Adult-onset Still's disease associated with collapsing glomerulopathy |
title | Adult-onset Still's disease associated with collapsing glomerulopathy |
title_full | Adult-onset Still's disease associated with collapsing glomerulopathy |
title_fullStr | Adult-onset Still's disease associated with collapsing glomerulopathy |
title_full_unstemmed | Adult-onset Still's disease associated with collapsing glomerulopathy |
title_short | Adult-onset Still's disease associated with collapsing glomerulopathy |
title_sort | adult-onset still's disease associated with collapsing glomerulopathy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421551/ https://www.ncbi.nlm.nih.gov/pubmed/25949406 http://dx.doi.org/10.1093/ndtplus/sfp114 |
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