Cargando…

Adult-onset Still's disease associated with collapsing glomerulopathy

A young woman of African descent presented with fevers, arthralgia, lymphadenopathy and a skin rash. Modest proteinuria was also noted. The clinical picture suggested an acute HIV sero-conversion illness, and a renal biopsy showed a collapsing glomerulopathy compatible with that diagnosis. However,...

Descripción completa

Detalles Bibliográficos
Autores principales: Arulkumaran, Nishkantha, Reitbock, Pablo, Halliday, Kirsty, Onwubalili, James, Jayasena, Dakshina, Dupont, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421551/
https://www.ncbi.nlm.nih.gov/pubmed/25949406
http://dx.doi.org/10.1093/ndtplus/sfp114
_version_ 1782369895143440384
author Arulkumaran, Nishkantha
Reitbock, Pablo
Halliday, Kirsty
Onwubalili, James
Jayasena, Dakshina
Dupont, Peter J.
author_facet Arulkumaran, Nishkantha
Reitbock, Pablo
Halliday, Kirsty
Onwubalili, James
Jayasena, Dakshina
Dupont, Peter J.
author_sort Arulkumaran, Nishkantha
collection PubMed
description A young woman of African descent presented with fevers, arthralgia, lymphadenopathy and a skin rash. Modest proteinuria was also noted. The clinical picture suggested an acute HIV sero-conversion illness, and a renal biopsy showed a collapsing glomerulopathy compatible with that diagnosis. However, HIV serology proved persistently negative and a diagnosis of Adult Still's disease was subsequently made (by Yamaguchi criteria). Following steroid treatment, the patient's fever abated and her inflammatory markers returned to normal. Collapsing glomerulopathy is a rare but important complication of Adult Still's disease. Immunosuppressive treatment may be effective in improving renal outcome.
format Online
Article
Text
id pubmed-4421551
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-44215512015-05-06 Adult-onset Still's disease associated with collapsing glomerulopathy Arulkumaran, Nishkantha Reitbock, Pablo Halliday, Kirsty Onwubalili, James Jayasena, Dakshina Dupont, Peter J. NDT Plus Case Report A young woman of African descent presented with fevers, arthralgia, lymphadenopathy and a skin rash. Modest proteinuria was also noted. The clinical picture suggested an acute HIV sero-conversion illness, and a renal biopsy showed a collapsing glomerulopathy compatible with that diagnosis. However, HIV serology proved persistently negative and a diagnosis of Adult Still's disease was subsequently made (by Yamaguchi criteria). Following steroid treatment, the patient's fever abated and her inflammatory markers returned to normal. Collapsing glomerulopathy is a rare but important complication of Adult Still's disease. Immunosuppressive treatment may be effective in improving renal outcome. Oxford University Press 2010-02 2009-08-26 /pmc/articles/PMC4421551/ /pubmed/25949406 http://dx.doi.org/10.1093/ndtplus/sfp114 Text en © The Author 2009. Published by Oxford University Press [on behalf of ERA-EDTA]. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Arulkumaran, Nishkantha
Reitbock, Pablo
Halliday, Kirsty
Onwubalili, James
Jayasena, Dakshina
Dupont, Peter J.
Adult-onset Still's disease associated with collapsing glomerulopathy
title Adult-onset Still's disease associated with collapsing glomerulopathy
title_full Adult-onset Still's disease associated with collapsing glomerulopathy
title_fullStr Adult-onset Still's disease associated with collapsing glomerulopathy
title_full_unstemmed Adult-onset Still's disease associated with collapsing glomerulopathy
title_short Adult-onset Still's disease associated with collapsing glomerulopathy
title_sort adult-onset still's disease associated with collapsing glomerulopathy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421551/
https://www.ncbi.nlm.nih.gov/pubmed/25949406
http://dx.doi.org/10.1093/ndtplus/sfp114
work_keys_str_mv AT arulkumarannishkantha adultonsetstillsdiseaseassociatedwithcollapsingglomerulopathy
AT reitbockpablo adultonsetstillsdiseaseassociatedwithcollapsingglomerulopathy
AT hallidaykirsty adultonsetstillsdiseaseassociatedwithcollapsingglomerulopathy
AT onwubalilijames adultonsetstillsdiseaseassociatedwithcollapsingglomerulopathy
AT jayasenadakshina adultonsetstillsdiseaseassociatedwithcollapsingglomerulopathy
AT dupontpeterj adultonsetstillsdiseaseassociatedwithcollapsingglomerulopathy