An unusual case of severe high anion gap metabolic acidosis

We present a case of high anion gap metabolic acidosis with an unusual aetiology in a 75-year-old lady with hypoglycaemia, encephalopathy and relatively preserved renal function. Full toxicology and biochemical analysis suggested that she had an inborn error of metabolism, riboflavin-responsive mult...

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Autores principales: Bavakunji, Riaz V., Turner, Jake D., Jujjavarapu, Sagar, Taal, Maarten W., Fluck, Richard J., Leung, Janson C., Kolhe, Nitin V., Selby, Nicholas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Clinical Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421581/
https://www.ncbi.nlm.nih.gov/pubmed/25984120
http://dx.doi.org/10.1093/ndtplus/sfr009
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author Bavakunji, Riaz V.
Turner, Jake D.
Jujjavarapu, Sagar
Taal, Maarten W.
Fluck, Richard J.
Leung, Janson C.
Kolhe, Nitin V.
Selby, Nicholas M.
author_facet Bavakunji, Riaz V.
Turner, Jake D.
Jujjavarapu, Sagar
Taal, Maarten W.
Fluck, Richard J.
Leung, Janson C.
Kolhe, Nitin V.
Selby, Nicholas M.
author_sort Bavakunji, Riaz V.
collection PubMed
description We present a case of high anion gap metabolic acidosis with an unusual aetiology in a 75-year-old lady with hypoglycaemia, encephalopathy and relatively preserved renal function. Full toxicology and biochemical analysis suggested that she had an inborn error of metabolism, riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency that can predispose to severe acidosis in situations where calorific intake is reduced. We believe this to be one of the few published cases and is remarkable for the presentation in late adulthood in addition to the requirement for emergency haemodialysis due to the severity of the metabolic disturbance.
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spelling pubmed-44215812015-05-15 An unusual case of severe high anion gap metabolic acidosis Bavakunji, Riaz V. Turner, Jake D. Jujjavarapu, Sagar Taal, Maarten W. Fluck, Richard J. Leung, Janson C. Kolhe, Nitin V. Selby, Nicholas M. NDT Plus Clinical Reports We present a case of high anion gap metabolic acidosis with an unusual aetiology in a 75-year-old lady with hypoglycaemia, encephalopathy and relatively preserved renal function. Full toxicology and biochemical analysis suggested that she had an inborn error of metabolism, riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency that can predispose to severe acidosis in situations where calorific intake is reduced. We believe this to be one of the few published cases and is remarkable for the presentation in late adulthood in addition to the requirement for emergency haemodialysis due to the severity of the metabolic disturbance. Oxford University Press 2011-04 2011-03-07 /pmc/articles/PMC4421581/ /pubmed/25984120 http://dx.doi.org/10.1093/ndtplus/sfr009 Text en © The Author 2011. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Clinical Reports
Bavakunji, Riaz V.
Turner, Jake D.
Jujjavarapu, Sagar
Taal, Maarten W.
Fluck, Richard J.
Leung, Janson C.
Kolhe, Nitin V.
Selby, Nicholas M.
An unusual case of severe high anion gap metabolic acidosis
title An unusual case of severe high anion gap metabolic acidosis
title_full An unusual case of severe high anion gap metabolic acidosis
title_fullStr An unusual case of severe high anion gap metabolic acidosis
title_full_unstemmed An unusual case of severe high anion gap metabolic acidosis
title_short An unusual case of severe high anion gap metabolic acidosis
title_sort unusual case of severe high anion gap metabolic acidosis
topic Clinical Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421581/
https://www.ncbi.nlm.nih.gov/pubmed/25984120
http://dx.doi.org/10.1093/ndtplus/sfr009
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