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Renal involvement in leishmaniasis: a review of the literature
Leishmaniasis, an infectious disease endemic in tropical, Asian and southern European countries, is caused by obligate intramacrophage protozoa and is transmitted through the bite of infected female sandflies. More than 20 leishmanial species are responsible for four main clinical syndromes: cutaneo...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421603/ https://www.ncbi.nlm.nih.gov/pubmed/25984144 http://dx.doi.org/10.1093/ndtplus/sfr008 |
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author | Clementi, Anna Battaglia, Giorgio Floris, Matteo Castellino, Pietro Ronco, Claudio Cruz, Dinna N. |
author_facet | Clementi, Anna Battaglia, Giorgio Floris, Matteo Castellino, Pietro Ronco, Claudio Cruz, Dinna N. |
author_sort | Clementi, Anna |
collection | PubMed |
description | Leishmaniasis, an infectious disease endemic in tropical, Asian and southern European countries, is caused by obligate intramacrophage protozoa and is transmitted through the bite of infected female sandflies. More than 20 leishmanial species are responsible for four main clinical syndromes: cutaneous leishmaniasis; mucocutaneous leishmaniasis; visceral leishmaniasis, also known as kala-azar, and post-kala-azar dermal leishmaniasis. Visceral leishmaniasis can present with varying clinical features and the kidney can also be involved. Both glomerular and tubular function can be altered and patients can develop proteinuria, haematuria, abnormalities in urinary concentration and acidification and acute and chronic renal insufficiency. Not only the disease itself but also the therapy administered might be responsible for the renal involvement in kala-azar. Indeed, some of the agents with efficiency against visceral leishmaniasis, such as pentavalent antimonial drugs, amphotericin B, pentamidine, miltefosine, paromomycin and simataquine, may be associated with a high risk of renal toxicity. In this article, the literature on renal involvement in visceral leishmaniasis is reviewed. |
format | Online Article Text |
id | pubmed-4421603 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-44216032015-05-15 Renal involvement in leishmaniasis: a review of the literature Clementi, Anna Battaglia, Giorgio Floris, Matteo Castellino, Pietro Ronco, Claudio Cruz, Dinna N. NDT Plus I. Special Features Leishmaniasis, an infectious disease endemic in tropical, Asian and southern European countries, is caused by obligate intramacrophage protozoa and is transmitted through the bite of infected female sandflies. More than 20 leishmanial species are responsible for four main clinical syndromes: cutaneous leishmaniasis; mucocutaneous leishmaniasis; visceral leishmaniasis, also known as kala-azar, and post-kala-azar dermal leishmaniasis. Visceral leishmaniasis can present with varying clinical features and the kidney can also be involved. Both glomerular and tubular function can be altered and patients can develop proteinuria, haematuria, abnormalities in urinary concentration and acidification and acute and chronic renal insufficiency. Not only the disease itself but also the therapy administered might be responsible for the renal involvement in kala-azar. Indeed, some of the agents with efficiency against visceral leishmaniasis, such as pentavalent antimonial drugs, amphotericin B, pentamidine, miltefosine, paromomycin and simataquine, may be associated with a high risk of renal toxicity. In this article, the literature on renal involvement in visceral leishmaniasis is reviewed. Oxford University Press 2011-06 2011-03-21 /pmc/articles/PMC4421603/ /pubmed/25984144 http://dx.doi.org/10.1093/ndtplus/sfr008 Text en © The Author 2011. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | I. Special Features Clementi, Anna Battaglia, Giorgio Floris, Matteo Castellino, Pietro Ronco, Claudio Cruz, Dinna N. Renal involvement in leishmaniasis: a review of the literature |
title | Renal involvement in leishmaniasis: a review of the literature |
title_full | Renal involvement in leishmaniasis: a review of the literature |
title_fullStr | Renal involvement in leishmaniasis: a review of the literature |
title_full_unstemmed | Renal involvement in leishmaniasis: a review of the literature |
title_short | Renal involvement in leishmaniasis: a review of the literature |
title_sort | renal involvement in leishmaniasis: a review of the literature |
topic | I. Special Features |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421603/ https://www.ncbi.nlm.nih.gov/pubmed/25984144 http://dx.doi.org/10.1093/ndtplus/sfr008 |
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