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Epstein–Barr virus-associated gastric carcinoma 33 years after kidney transplantation
Epstein–Barr virus-associated gastric carcinoma (EBVaGC) is a unique type of gastric cancer, defined as the presence of EBV in gastric tumour cells, usually identified by in situ hybridization. A poorly differentiated gastric adenocarcinoma was detected in a kidney recipient 33 years after transplan...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421642/ https://www.ncbi.nlm.nih.gov/pubmed/25984103 http://dx.doi.org/10.1093/ndtplus/sfq197 |
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author | Lunardi, Francesca Calabrese, Fiorella Furian, Lucrezia Rigotti, Paolo Valente, Marialuisa |
author_facet | Lunardi, Francesca Calabrese, Fiorella Furian, Lucrezia Rigotti, Paolo Valente, Marialuisa |
author_sort | Lunardi, Francesca |
collection | PubMed |
description | Epstein–Barr virus-associated gastric carcinoma (EBVaGC) is a unique type of gastric cancer, defined as the presence of EBV in gastric tumour cells, usually identified by in situ hybridization. A poorly differentiated gastric adenocarcinoma was detected in a kidney recipient 33 years after transplantation. Neoplastic epithelial cells were EBV positive by in situ hybridization. Gene sequencing confirmed the amplicon specificity, and real-time polymerase chain reaction quantified 2 600 000 genomes/μL DNA in neoplastic tissue. No cases of EBVaGC have been reported in solid organ transplants, thus this is the first case of de novo EBVaGC arising in a 65-year-old renal transplant recipient. |
format | Online Article Text |
id | pubmed-4421642 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-44216422015-05-15 Epstein–Barr virus-associated gastric carcinoma 33 years after kidney transplantation Lunardi, Francesca Calabrese, Fiorella Furian, Lucrezia Rigotti, Paolo Valente, Marialuisa NDT Plus Case Report Epstein–Barr virus-associated gastric carcinoma (EBVaGC) is a unique type of gastric cancer, defined as the presence of EBV in gastric tumour cells, usually identified by in situ hybridization. A poorly differentiated gastric adenocarcinoma was detected in a kidney recipient 33 years after transplantation. Neoplastic epithelial cells were EBV positive by in situ hybridization. Gene sequencing confirmed the amplicon specificity, and real-time polymerase chain reaction quantified 2 600 000 genomes/μL DNA in neoplastic tissue. No cases of EBVaGC have been reported in solid organ transplants, thus this is the first case of de novo EBVaGC arising in a 65-year-old renal transplant recipient. Oxford University Press 2011-02 2010-12-10 /pmc/articles/PMC4421642/ /pubmed/25984103 http://dx.doi.org/10.1093/ndtplus/sfq197 Text en © The Author 2010. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Case Report Lunardi, Francesca Calabrese, Fiorella Furian, Lucrezia Rigotti, Paolo Valente, Marialuisa Epstein–Barr virus-associated gastric carcinoma 33 years after kidney transplantation |
title | Epstein–Barr virus-associated gastric carcinoma 33 years after kidney transplantation |
title_full | Epstein–Barr virus-associated gastric carcinoma 33 years after kidney transplantation |
title_fullStr | Epstein–Barr virus-associated gastric carcinoma 33 years after kidney transplantation |
title_full_unstemmed | Epstein–Barr virus-associated gastric carcinoma 33 years after kidney transplantation |
title_short | Epstein–Barr virus-associated gastric carcinoma 33 years after kidney transplantation |
title_sort | epstein–barr virus-associated gastric carcinoma 33 years after kidney transplantation |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421642/ https://www.ncbi.nlm.nih.gov/pubmed/25984103 http://dx.doi.org/10.1093/ndtplus/sfq197 |
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