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Epstein–Barr virus-associated gastric carcinoma 33 years after kidney transplantation

Epstein–Barr virus-associated gastric carcinoma (EBVaGC) is a unique type of gastric cancer, defined as the presence of EBV in gastric tumour cells, usually identified by in situ hybridization. A poorly differentiated gastric adenocarcinoma was detected in a kidney recipient 33 years after transplan...

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Detalles Bibliográficos
Autores principales: Lunardi, Francesca, Calabrese, Fiorella, Furian, Lucrezia, Rigotti, Paolo, Valente, Marialuisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421642/
https://www.ncbi.nlm.nih.gov/pubmed/25984103
http://dx.doi.org/10.1093/ndtplus/sfq197
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author Lunardi, Francesca
Calabrese, Fiorella
Furian, Lucrezia
Rigotti, Paolo
Valente, Marialuisa
author_facet Lunardi, Francesca
Calabrese, Fiorella
Furian, Lucrezia
Rigotti, Paolo
Valente, Marialuisa
author_sort Lunardi, Francesca
collection PubMed
description Epstein–Barr virus-associated gastric carcinoma (EBVaGC) is a unique type of gastric cancer, defined as the presence of EBV in gastric tumour cells, usually identified by in situ hybridization. A poorly differentiated gastric adenocarcinoma was detected in a kidney recipient 33 years after transplantation. Neoplastic epithelial cells were EBV positive by in situ hybridization. Gene sequencing confirmed the amplicon specificity, and real-time polymerase chain reaction quantified 2 600 000 genomes/μL DNA in neoplastic tissue. No cases of EBVaGC have been reported in solid organ transplants, thus this is the first case of de novo EBVaGC arising in a 65-year-old renal transplant recipient.
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spelling pubmed-44216422015-05-15 Epstein–Barr virus-associated gastric carcinoma 33 years after kidney transplantation Lunardi, Francesca Calabrese, Fiorella Furian, Lucrezia Rigotti, Paolo Valente, Marialuisa NDT Plus Case Report Epstein–Barr virus-associated gastric carcinoma (EBVaGC) is a unique type of gastric cancer, defined as the presence of EBV in gastric tumour cells, usually identified by in situ hybridization. A poorly differentiated gastric adenocarcinoma was detected in a kidney recipient 33 years after transplantation. Neoplastic epithelial cells were EBV positive by in situ hybridization. Gene sequencing confirmed the amplicon specificity, and real-time polymerase chain reaction quantified 2 600 000 genomes/μL DNA in neoplastic tissue. No cases of EBVaGC have been reported in solid organ transplants, thus this is the first case of de novo EBVaGC arising in a 65-year-old renal transplant recipient. Oxford University Press 2011-02 2010-12-10 /pmc/articles/PMC4421642/ /pubmed/25984103 http://dx.doi.org/10.1093/ndtplus/sfq197 Text en © The Author 2010. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Lunardi, Francesca
Calabrese, Fiorella
Furian, Lucrezia
Rigotti, Paolo
Valente, Marialuisa
Epstein–Barr virus-associated gastric carcinoma 33 years after kidney transplantation
title Epstein–Barr virus-associated gastric carcinoma 33 years after kidney transplantation
title_full Epstein–Barr virus-associated gastric carcinoma 33 years after kidney transplantation
title_fullStr Epstein–Barr virus-associated gastric carcinoma 33 years after kidney transplantation
title_full_unstemmed Epstein–Barr virus-associated gastric carcinoma 33 years after kidney transplantation
title_short Epstein–Barr virus-associated gastric carcinoma 33 years after kidney transplantation
title_sort epstein–barr virus-associated gastric carcinoma 33 years after kidney transplantation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421642/
https://www.ncbi.nlm.nih.gov/pubmed/25984103
http://dx.doi.org/10.1093/ndtplus/sfq197
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