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Scorpion sting nephropathy
Scorpion envenomations are ubiquitous, but nephropathy is a rare manifestation, reported mainly from the Middle East and North Africa. Rapid venom redistribution from blood, delayed excretion from the kidneys, direct toxicity of venom enzymes, cytokine release and afferent arteriolar constriction ha...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421667/ https://www.ncbi.nlm.nih.gov/pubmed/25984198 http://dx.doi.org/10.1093/ndtplus/sfr148 |
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author | Viswanathan, Stalin Prabhu, Chaitanya |
author_facet | Viswanathan, Stalin Prabhu, Chaitanya |
author_sort | Viswanathan, Stalin |
collection | PubMed |
description | Scorpion envenomations are ubiquitous, but nephropathy is a rare manifestation, reported mainly from the Middle East and North Africa. Rapid venom redistribution from blood, delayed excretion from the kidneys, direct toxicity of venom enzymes, cytokine release and afferent arteriolar constriction have been seen in experimental animals. Haemoglobinuria, acute tubular necrosis, interstitial nephritis and haemolytic–uraemic syndrome have been documented in human victims of scorpion envenomation. Epidemiology, venom components and toxins, effects on the laboratory mammals especially the kidneys and reports of renal failure in humans are reviewed in this article. |
format | Online Article Text |
id | pubmed-4421667 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-44216672015-05-15 Scorpion sting nephropathy Viswanathan, Stalin Prabhu, Chaitanya NDT Plus I. Special Features Scorpion envenomations are ubiquitous, but nephropathy is a rare manifestation, reported mainly from the Middle East and North Africa. Rapid venom redistribution from blood, delayed excretion from the kidneys, direct toxicity of venom enzymes, cytokine release and afferent arteriolar constriction have been seen in experimental animals. Haemoglobinuria, acute tubular necrosis, interstitial nephritis and haemolytic–uraemic syndrome have been documented in human victims of scorpion envenomation. Epidemiology, venom components and toxins, effects on the laboratory mammals especially the kidneys and reports of renal failure in humans are reviewed in this article. Oxford University Press 2011-12 /pmc/articles/PMC4421667/ /pubmed/25984198 http://dx.doi.org/10.1093/ndtplus/sfr148 Text en © The Author 2011. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | I. Special Features Viswanathan, Stalin Prabhu, Chaitanya Scorpion sting nephropathy |
title | Scorpion sting nephropathy |
title_full | Scorpion sting nephropathy |
title_fullStr | Scorpion sting nephropathy |
title_full_unstemmed | Scorpion sting nephropathy |
title_short | Scorpion sting nephropathy |
title_sort | scorpion sting nephropathy |
topic | I. Special Features |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421667/ https://www.ncbi.nlm.nih.gov/pubmed/25984198 http://dx.doi.org/10.1093/ndtplus/sfr148 |
work_keys_str_mv | AT viswanathanstalin scorpionstingnephropathy AT prabhuchaitanya scorpionstingnephropathy |