Extreme lactic acidosis type B associated with metformin treatment

The elimination of metformin is exclusively through the kidneys and elevated plasma concentrations can cause lactic acidosis. We report a case of severe lactic acidosis (pH 6.60) occuring with ostensibly normal therapeutic doses of metformin in the setting of acute renal failure. Continuous veno-ven...

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Autores principales: Pikwer, Andreas, Vernersson, Einar, Frid, Anders, Sterner, Gunnar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
II. Clinical Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421670/
https://www.ncbi.nlm.nih.gov/pubmed/25984205
http://dx.doi.org/10.1093/ndtplus/sfr110
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author Pikwer, Andreas
Vernersson, Einar
Frid, Anders
Sterner, Gunnar
author_facet Pikwer, Andreas
Vernersson, Einar
Frid, Anders
Sterner, Gunnar
author_sort Pikwer, Andreas
collection PubMed
description The elimination of metformin is exclusively through the kidneys and elevated plasma concentrations can cause lactic acidosis. We report a case of severe lactic acidosis (pH 6.60) occuring with ostensibly normal therapeutic doses of metformin in the setting of acute renal failure. Continuous veno-venous haemodiafiltration decreased plasma metformin concentrations from 266 lmol/L at presentation to 68 lmol/L, 21 h later. The patient improved rapidly.
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spelling pubmed-44216702015-05-15 Extreme lactic acidosis type B associated with metformin treatment Pikwer, Andreas Vernersson, Einar Frid, Anders Sterner, Gunnar NDT Plus II. Clinical Reports The elimination of metformin is exclusively through the kidneys and elevated plasma concentrations can cause lactic acidosis. We report a case of severe lactic acidosis (pH 6.60) occuring with ostensibly normal therapeutic doses of metformin in the setting of acute renal failure. Continuous veno-venous haemodiafiltration decreased plasma metformin concentrations from 266 lmol/L at presentation to 68 lmol/L, 21 h later. The patient improved rapidly. Oxford University Press 2011-12 2011-09-14 /pmc/articles/PMC4421670/ /pubmed/25984205 http://dx.doi.org/10.1093/ndtplus/sfr110 Text en © The Author 2011. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle II. Clinical Reports
Pikwer, Andreas
Vernersson, Einar
Frid, Anders
Sterner, Gunnar
Extreme lactic acidosis type B associated with metformin treatment
title Extreme lactic acidosis type B associated with metformin treatment
title_full Extreme lactic acidosis type B associated with metformin treatment
title_fullStr Extreme lactic acidosis type B associated with metformin treatment
title_full_unstemmed Extreme lactic acidosis type B associated with metformin treatment
title_short Extreme lactic acidosis type B associated with metformin treatment
title_sort extreme lactic acidosis type b associated with metformin treatment
topic II. Clinical Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421670/
https://www.ncbi.nlm.nih.gov/pubmed/25984205
http://dx.doi.org/10.1093/ndtplus/sfr110
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