Is thrombotic microangiopathy a paraneoplastic phenomenon? Case report and review of the literature

It is currently recognized that the pathogenesis of malignancy-associated thrombotic microangiopathy (TMA) is distinct from thrombotic thrombocytopenic purpura. This carries important implications in its classification and its management. Here, we report a case of occult malignancy presenting initia...

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Detalles Bibliográficos
Autores principales: Houston, Simon A., Hegele, Richard G., Sugar, Linda, Colak, Errol, Pavenski, Katerina, Allo, Ghassan, Perl, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
II. Clinical Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421736/
https://www.ncbi.nlm.nih.gov/pubmed/25984172
http://dx.doi.org/10.1093/ndtplus/sfr085
Descripción
Sumario:It is currently recognized that the pathogenesis of malignancy-associated thrombotic microangiopathy (TMA) is distinct from thrombotic thrombocytopenic purpura. This carries important implications in its classification and its management. Here, we report a case of occult malignancy presenting initially as acute kidney injury secondary to TMA and highlight the importance of considering an underlying malignancy in patients not responding to conventional therapy for TMA.

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