Is thrombotic microangiopathy a paraneoplastic phenomenon? Case report and review of the literature

It is currently recognized that the pathogenesis of malignancy-associated thrombotic microangiopathy (TMA) is distinct from thrombotic thrombocytopenic purpura. This carries important implications in its classification and its management. Here, we report a case of occult malignancy presenting initia...

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Autores principales: Houston, Simon A., Hegele, Richard G., Sugar, Linda, Colak, Errol, Pavenski, Katerina, Allo, Ghassan, Perl, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
II. Clinical Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421736/
https://www.ncbi.nlm.nih.gov/pubmed/25984172
http://dx.doi.org/10.1093/ndtplus/sfr085
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author Houston, Simon A.
Hegele, Richard G.
Sugar, Linda
Colak, Errol
Pavenski, Katerina
Allo, Ghassan
Perl, Jeffrey
author_facet Houston, Simon A.
Hegele, Richard G.
Sugar, Linda
Colak, Errol
Pavenski, Katerina
Allo, Ghassan
Perl, Jeffrey
author_sort Houston, Simon A.
collection PubMed
description It is currently recognized that the pathogenesis of malignancy-associated thrombotic microangiopathy (TMA) is distinct from thrombotic thrombocytopenic purpura. This carries important implications in its classification and its management. Here, we report a case of occult malignancy presenting initially as acute kidney injury secondary to TMA and highlight the importance of considering an underlying malignancy in patients not responding to conventional therapy for TMA.
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spelling pubmed-44217362015-05-15 Is thrombotic microangiopathy a paraneoplastic phenomenon? Case report and review of the literature Houston, Simon A. Hegele, Richard G. Sugar, Linda Colak, Errol Pavenski, Katerina Allo, Ghassan Perl, Jeffrey NDT Plus II. Clinical Reports It is currently recognized that the pathogenesis of malignancy-associated thrombotic microangiopathy (TMA) is distinct from thrombotic thrombocytopenic purpura. This carries important implications in its classification and its management. Here, we report a case of occult malignancy presenting initially as acute kidney injury secondary to TMA and highlight the importance of considering an underlying malignancy in patients not responding to conventional therapy for TMA. Oxford University Press 2011-10 2011-07-27 /pmc/articles/PMC4421736/ /pubmed/25984172 http://dx.doi.org/10.1093/ndtplus/sfr085 Text en © The Author 2011. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle II. Clinical Reports
Houston, Simon A.
Hegele, Richard G.
Sugar, Linda
Colak, Errol
Pavenski, Katerina
Allo, Ghassan
Perl, Jeffrey
Is thrombotic microangiopathy a paraneoplastic phenomenon? Case report and review of the literature
title Is thrombotic microangiopathy a paraneoplastic phenomenon? Case report and review of the literature
title_full Is thrombotic microangiopathy a paraneoplastic phenomenon? Case report and review of the literature
title_fullStr Is thrombotic microangiopathy a paraneoplastic phenomenon? Case report and review of the literature
title_full_unstemmed Is thrombotic microangiopathy a paraneoplastic phenomenon? Case report and review of the literature
title_short Is thrombotic microangiopathy a paraneoplastic phenomenon? Case report and review of the literature
title_sort is thrombotic microangiopathy a paraneoplastic phenomenon? case report and review of the literature
topic II. Clinical Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421736/
https://www.ncbi.nlm.nih.gov/pubmed/25984172
http://dx.doi.org/10.1093/ndtplus/sfr085
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