A case of endocapillary glomerulonephritis associated with peripheral blood natural killer cell proliferation

A 69-year-old male was admitted to our hospital due to rapidly progressive glomerulonephritis. A peripheral blood smear showed a marked increase in large granular lymphocytes. Flow cytometry analysis of the blood showed a marked increase in CD3-negative and CD56-positive natural killer (NK) cells. A...

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Autores principales: Kishi, Tomoya, Ikeda, Yuji, Miyazono, Motoaki, Fukushima, Noriyasu, Aoki, Shigehisa, Sanai, Toru, Sakemi, Takanobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
II. Clinical Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421738/
https://www.ncbi.nlm.nih.gov/pubmed/25984176
http://dx.doi.org/10.1093/ndtplus/sfr086
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author Kishi, Tomoya
Ikeda, Yuji
Miyazono, Motoaki
Fukushima, Noriyasu
Aoki, Shigehisa
Sanai, Toru
Sakemi, Takanobu
author_facet Kishi, Tomoya
Ikeda, Yuji
Miyazono, Motoaki
Fukushima, Noriyasu
Aoki, Shigehisa
Sanai, Toru
Sakemi, Takanobu
author_sort Kishi, Tomoya
collection PubMed
description A 69-year-old male was admitted to our hospital due to rapidly progressive glomerulonephritis. A peripheral blood smear showed a marked increase in large granular lymphocytes. Flow cytometry analysis of the blood showed a marked increase in CD3-negative and CD56-positive natural killer (NK) cells. A renal biopsy showed a characteristic pathological pattern that involved endocapillary proliferation, a predominance of mononuclear cells and mesangiolysis. Prednisolone was administered, and the patient’s renal function subsequently improved concomitant with the amelioration of NK cell proliferation. In our case, there was evidence of a strong association between NK cell proliferation and glomerulonephritis.
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spelling pubmed-44217382015-05-15 A case of endocapillary glomerulonephritis associated with peripheral blood natural killer cell proliferation Kishi, Tomoya Ikeda, Yuji Miyazono, Motoaki Fukushima, Noriyasu Aoki, Shigehisa Sanai, Toru Sakemi, Takanobu NDT Plus II. Clinical Reports A 69-year-old male was admitted to our hospital due to rapidly progressive glomerulonephritis. A peripheral blood smear showed a marked increase in large granular lymphocytes. Flow cytometry analysis of the blood showed a marked increase in CD3-negative and CD56-positive natural killer (NK) cells. A renal biopsy showed a characteristic pathological pattern that involved endocapillary proliferation, a predominance of mononuclear cells and mesangiolysis. Prednisolone was administered, and the patient’s renal function subsequently improved concomitant with the amelioration of NK cell proliferation. In our case, there was evidence of a strong association between NK cell proliferation and glomerulonephritis. Oxford University Press 2011-10 2011-07-27 /pmc/articles/PMC4421738/ /pubmed/25984176 http://dx.doi.org/10.1093/ndtplus/sfr086 Text en © The Author 2011. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle II. Clinical Reports
Kishi, Tomoya
Ikeda, Yuji
Miyazono, Motoaki
Fukushima, Noriyasu
Aoki, Shigehisa
Sanai, Toru
Sakemi, Takanobu
A case of endocapillary glomerulonephritis associated with peripheral blood natural killer cell proliferation
title A case of endocapillary glomerulonephritis associated with peripheral blood natural killer cell proliferation
title_full A case of endocapillary glomerulonephritis associated with peripheral blood natural killer cell proliferation
title_fullStr A case of endocapillary glomerulonephritis associated with peripheral blood natural killer cell proliferation
title_full_unstemmed A case of endocapillary glomerulonephritis associated with peripheral blood natural killer cell proliferation
title_short A case of endocapillary glomerulonephritis associated with peripheral blood natural killer cell proliferation
title_sort case of endocapillary glomerulonephritis associated with peripheral blood natural killer cell proliferation
topic II. Clinical Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421738/
https://www.ncbi.nlm.nih.gov/pubmed/25984176
http://dx.doi.org/10.1093/ndtplus/sfr086
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