A cluster of noncoding RNAs activates the ESR1 locus during breast cancer adaptation

Estrogen receptor-α (ER)-positive breast cancer cells undergo hormone-independent proliferation after deprivation of oestrogen, leading to endocrine therapy resistance. Up-regulation of the ER gene (ESR1) is critical for this process, but the underlying mechanisms remain unclear. Here we show that t...

Descripción completa

Detalles Bibliográficos
Autores principales: Tomita, Saori, Abdalla, Mohamed Osama Ali, Fujiwara, Saori, Matsumori, Haruka, Maehara, Kazumitsu, Ohkawa, Yasuyuki, Iwase, Hirotaka, Saitoh, Noriko, Nakao, Mitsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421845/
https://www.ncbi.nlm.nih.gov/pubmed/25923108
http://dx.doi.org/10.1038/ncomms7966

Ejemplares similares

Ejemplares similares