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What is the point of pseudokinases?

The interaction between an active kinase and an ‘inactive’ pseudokinase provides clues about how these enzymes were regulated in the past, and how this regulation has evolved.

Detalles Bibliográficos
Autores principales: Raju, Saravanan, Shaw, Andrey S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421857/
https://www.ncbi.nlm.nih.gov/pubmed/25946107
http://dx.doi.org/10.7554/eLife.07771
Descripción
Sumario:The interaction between an active kinase and an ‘inactive’ pseudokinase provides clues about how these enzymes were regulated in the past, and how this regulation has evolved.