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Epigenetic regulation of gene expression in osteoarthritis
Osteoarthritis (OA) is the most common form of joint disease and the leading cause of chronic disability in middle-aged and older populations. The development of disease-modifying therapy for OA currently faces major obstacles largely because the regulatory mechanisms for the function of joint tissu...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chongqing Medical University
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421878/ https://www.ncbi.nlm.nih.gov/pubmed/25961070 http://dx.doi.org/10.1016/j.gendis.2014.12.005 |
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author | Zhang, Mingcai Wang, Jinxi |
author_facet | Zhang, Mingcai Wang, Jinxi |
author_sort | Zhang, Mingcai |
collection | PubMed |
description | Osteoarthritis (OA) is the most common form of joint disease and the leading cause of chronic disability in middle-aged and older populations. The development of disease-modifying therapy for OA currently faces major obstacles largely because the regulatory mechanisms for the function of joint tissue cells remain unclear. Previous studies have found that the alterations in gene expression of specific transcription factors (TFs), pro- or anti-inflammatory cytokines, matrix proteinases and extracellular matrix (ECM) proteins in articular cartilage may be involved in the development of OA. However, the regulatory mechanisms for the expression of those genes in OA chondrocytes are largely unknown. The recent advances in epigenetic studies have shed light on the importance of epigenetic regulation of gene expression in the development of OA. In this review, we summarize and discuss the recent studies on the regulatory roles of various epigenetic mechanisms in the expression of genes for specific TFs, cytokines, ECM proteins and matrix proteinases, as well the significance of these epigenetic mechanisms in the pathogenesis of OA. |
format | Online Article Text |
id | pubmed-4421878 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Chongqing Medical University |
record_format | MEDLINE/PubMed |
spelling | pubmed-44218782016-03-01 Epigenetic regulation of gene expression in osteoarthritis Zhang, Mingcai Wang, Jinxi Genes Dis Article Osteoarthritis (OA) is the most common form of joint disease and the leading cause of chronic disability in middle-aged and older populations. The development of disease-modifying therapy for OA currently faces major obstacles largely because the regulatory mechanisms for the function of joint tissue cells remain unclear. Previous studies have found that the alterations in gene expression of specific transcription factors (TFs), pro- or anti-inflammatory cytokines, matrix proteinases and extracellular matrix (ECM) proteins in articular cartilage may be involved in the development of OA. However, the regulatory mechanisms for the expression of those genes in OA chondrocytes are largely unknown. The recent advances in epigenetic studies have shed light on the importance of epigenetic regulation of gene expression in the development of OA. In this review, we summarize and discuss the recent studies on the regulatory roles of various epigenetic mechanisms in the expression of genes for specific TFs, cytokines, ECM proteins and matrix proteinases, as well the significance of these epigenetic mechanisms in the pathogenesis of OA. Chongqing Medical University 2015-01-09 /pmc/articles/PMC4421878/ /pubmed/25961070 http://dx.doi.org/10.1016/j.gendis.2014.12.005 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Zhang, Mingcai Wang, Jinxi Epigenetic regulation of gene expression in osteoarthritis |
title | Epigenetic regulation of gene expression in osteoarthritis |
title_full | Epigenetic regulation of gene expression in osteoarthritis |
title_fullStr | Epigenetic regulation of gene expression in osteoarthritis |
title_full_unstemmed | Epigenetic regulation of gene expression in osteoarthritis |
title_short | Epigenetic regulation of gene expression in osteoarthritis |
title_sort | epigenetic regulation of gene expression in osteoarthritis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421878/ https://www.ncbi.nlm.nih.gov/pubmed/25961070 http://dx.doi.org/10.1016/j.gendis.2014.12.005 |
work_keys_str_mv | AT zhangmingcai epigeneticregulationofgeneexpressioninosteoarthritis AT wangjinxi epigeneticregulationofgeneexpressioninosteoarthritis |