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The end of the message: multiple protein–RNA interactions define the mRNA polyadenylation site
The key RNA sequence elements and protein factors necessary for 3′ processing of polyadenylated mRNA precursors are well known. Recent studies, however, have significantly reshaped current models for the protein–RNA interactions involved in poly(A) site recognition, painting a picture more complex t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421977/ https://www.ncbi.nlm.nih.gov/pubmed/25934501 http://dx.doi.org/10.1101/gad.261974.115 |
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author | Shi, Yongsheng Manley, James L. |
author_facet | Shi, Yongsheng Manley, James L. |
author_sort | Shi, Yongsheng |
collection | PubMed |
description | The key RNA sequence elements and protein factors necessary for 3′ processing of polyadenylated mRNA precursors are well known. Recent studies, however, have significantly reshaped current models for the protein–RNA interactions involved in poly(A) site recognition, painting a picture more complex than previously envisioned and also providing new insights into regulation of this important step in gene expression. Here we review the recent advances in this area and provide a perspective for future studies. |
format | Online Article Text |
id | pubmed-4421977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-44219772015-11-01 The end of the message: multiple protein–RNA interactions define the mRNA polyadenylation site Shi, Yongsheng Manley, James L. Genes Dev Review The key RNA sequence elements and protein factors necessary for 3′ processing of polyadenylated mRNA precursors are well known. Recent studies, however, have significantly reshaped current models for the protein–RNA interactions involved in poly(A) site recognition, painting a picture more complex than previously envisioned and also providing new insights into regulation of this important step in gene expression. Here we review the recent advances in this area and provide a perspective for future studies. Cold Spring Harbor Laboratory Press 2015-05-01 /pmc/articles/PMC4421977/ /pubmed/25934501 http://dx.doi.org/10.1101/gad.261974.115 Text en © 2015 Shi and Manley; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Review Shi, Yongsheng Manley, James L. The end of the message: multiple protein–RNA interactions define the mRNA polyadenylation site |
title | The end of the message: multiple protein–RNA interactions define the mRNA polyadenylation site |
title_full | The end of the message: multiple protein–RNA interactions define the mRNA polyadenylation site |
title_fullStr | The end of the message: multiple protein–RNA interactions define the mRNA polyadenylation site |
title_full_unstemmed | The end of the message: multiple protein–RNA interactions define the mRNA polyadenylation site |
title_short | The end of the message: multiple protein–RNA interactions define the mRNA polyadenylation site |
title_sort | end of the message: multiple protein–rna interactions define the mrna polyadenylation site |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421977/ https://www.ncbi.nlm.nih.gov/pubmed/25934501 http://dx.doi.org/10.1101/gad.261974.115 |
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