Exosomal lncRNA-p21 levels may help to distinguish prostate cancer from benign disease

Exosomes are membranous vesicles containing various biomolecules including lncRNAs which are involved in cellular communication and are secreted from many cells including cancer cells. In our study, investigated the exosomal GAS5 and lincRNA-p21 lncRNA levels in urine samples from 30 patients with p...

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Autores principales: Işın, Mustafa, Uysaler, Ege, Özgür, Emre, Köseoğlu, Hikmet, Şanlı, Öner, Yücel, Ömer B., Gezer, Uğur, Dalay, Nejat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422020/
https://www.ncbi.nlm.nih.gov/pubmed/25999983
http://dx.doi.org/10.3389/fgene.2015.00168
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author Işın, Mustafa
Uysaler, Ege
Özgür, Emre
Köseoğlu, Hikmet
Şanlı, Öner
Yücel, Ömer B.
Gezer, Uğur
Dalay, Nejat
author_facet Işın, Mustafa
Uysaler, Ege
Özgür, Emre
Köseoğlu, Hikmet
Şanlı, Öner
Yücel, Ömer B.
Gezer, Uğur
Dalay, Nejat
author_sort Işın, Mustafa
collection PubMed
description Exosomes are membranous vesicles containing various biomolecules including lncRNAs which are involved in cellular communication and are secreted from many cells including cancer cells. In our study, investigated the exosomal GAS5 and lincRNA-p21 lncRNA levels in urine samples from 30 patients with prostate cancer (PCa) and 49 patients with benign prostatic hyperplasia. Quantification of lncRNA molecules was performed by real-time PCR. We observed a significant difference in the exosomal lincRNA-p21 levels between PCa and BPH patients whereas the GAS5 levels did not reveal a difference. Our data suggest that the discriminative potential of exosomal lincRNA-p21 levels may help to improve the diagnostic prediction of the malignant state for patients with PCa.
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spelling pubmed-44220202015-05-21 Exosomal lncRNA-p21 levels may help to distinguish prostate cancer from benign disease Işın, Mustafa Uysaler, Ege Özgür, Emre Köseoğlu, Hikmet Şanlı, Öner Yücel, Ömer B. Gezer, Uğur Dalay, Nejat Front Genet Genetics Exosomes are membranous vesicles containing various biomolecules including lncRNAs which are involved in cellular communication and are secreted from many cells including cancer cells. In our study, investigated the exosomal GAS5 and lincRNA-p21 lncRNA levels in urine samples from 30 patients with prostate cancer (PCa) and 49 patients with benign prostatic hyperplasia. Quantification of lncRNA molecules was performed by real-time PCR. We observed a significant difference in the exosomal lincRNA-p21 levels between PCa and BPH patients whereas the GAS5 levels did not reveal a difference. Our data suggest that the discriminative potential of exosomal lincRNA-p21 levels may help to improve the diagnostic prediction of the malignant state for patients with PCa. Frontiers Media S.A. 2015-05-06 /pmc/articles/PMC4422020/ /pubmed/25999983 http://dx.doi.org/10.3389/fgene.2015.00168 Text en Copyright © 2015 Işın, Uysaler, Özgür, Köseoglu, Şanlı, Yücel, Gezer and Dalay. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Işın, Mustafa
Uysaler, Ege
Özgür, Emre
Köseoğlu, Hikmet
Şanlı, Öner
Yücel, Ömer B.
Gezer, Uğur
Dalay, Nejat
Exosomal lncRNA-p21 levels may help to distinguish prostate cancer from benign disease
title Exosomal lncRNA-p21 levels may help to distinguish prostate cancer from benign disease
title_full Exosomal lncRNA-p21 levels may help to distinguish prostate cancer from benign disease
title_fullStr Exosomal lncRNA-p21 levels may help to distinguish prostate cancer from benign disease
title_full_unstemmed Exosomal lncRNA-p21 levels may help to distinguish prostate cancer from benign disease
title_short Exosomal lncRNA-p21 levels may help to distinguish prostate cancer from benign disease
title_sort exosomal lncrna-p21 levels may help to distinguish prostate cancer from benign disease
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422020/
https://www.ncbi.nlm.nih.gov/pubmed/25999983
http://dx.doi.org/10.3389/fgene.2015.00168
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