Cargando…

Pre-stimulus BOLD-network activation modulates EEG spectral activity during working memory retention

Working memory (WM) processes depend on our momentary mental state and therefore exhibit considerable fluctuations. Here, we investigate the interplay of task-preparatory and task-related brain activity as represented by pre-stimulus BOLD-fluctuations and spectral EEG from the retention periods of a...

Descripción completa

Detalles Bibliográficos
Autores principales: Kottlow, Mara, Schlaepfer, Anthony, Baenninger, Anja, Michels, Lars, Brandeis, Daniel, Koenig, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422031/
https://www.ncbi.nlm.nih.gov/pubmed/25999828
http://dx.doi.org/10.3389/fnbeh.2015.00111
_version_ 1782369998570782720
author Kottlow, Mara
Schlaepfer, Anthony
Baenninger, Anja
Michels, Lars
Brandeis, Daniel
Koenig, Thomas
author_facet Kottlow, Mara
Schlaepfer, Anthony
Baenninger, Anja
Michels, Lars
Brandeis, Daniel
Koenig, Thomas
author_sort Kottlow, Mara
collection PubMed
description Working memory (WM) processes depend on our momentary mental state and therefore exhibit considerable fluctuations. Here, we investigate the interplay of task-preparatory and task-related brain activity as represented by pre-stimulus BOLD-fluctuations and spectral EEG from the retention periods of a visual WM task. Visual WM is used to maintain sensory information in the brain enabling the performance of cognitive operations and is associated with mental health. We tested 22 subjects simultaneously with EEG and fMRI while performing a visuo-verbal Sternberg task with two different loads, allowing for the temporal separation of preparation, encoding, retention and retrieval periods. Four temporally coherent networks (TCNs)—the default mode network (DMN), the dorsal attention, the right and the left WM network—were extracted from the continuous BOLD data by means of a group ICA. Subsequently, the modulatory effect of these networks' pre-stimulus activation upon retention-related EEG activity in the theta, alpha, and beta frequencies was analyzed. The obtained results are informative in the context of state-dependent information processing. We were able to replicate two well-known load-dependent effects: the frontal-midline theta increase during the task and the decrease of pre-stimulus DMN activity. As our main finding, these two measures seem to depend on each other as the significant negative correlations at frontal-midline channels suggested. Thus, suppressed pre-stimulus DMN levels facilitated later task related frontal midline theta increases. In general, based on previous findings that neuronal coupling in different frequency bands may underlie distinct functions in WM retention, our results suggest that processes reflected by spectral oscillations during retention seem not only to be “online” synchronized with activity in different attention-related networks but are also modulated by activity in these networks during preparation intervals.
format Online
Article
Text
id pubmed-4422031
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-44220312015-05-21 Pre-stimulus BOLD-network activation modulates EEG spectral activity during working memory retention Kottlow, Mara Schlaepfer, Anthony Baenninger, Anja Michels, Lars Brandeis, Daniel Koenig, Thomas Front Behav Neurosci Neuroscience Working memory (WM) processes depend on our momentary mental state and therefore exhibit considerable fluctuations. Here, we investigate the interplay of task-preparatory and task-related brain activity as represented by pre-stimulus BOLD-fluctuations and spectral EEG from the retention periods of a visual WM task. Visual WM is used to maintain sensory information in the brain enabling the performance of cognitive operations and is associated with mental health. We tested 22 subjects simultaneously with EEG and fMRI while performing a visuo-verbal Sternberg task with two different loads, allowing for the temporal separation of preparation, encoding, retention and retrieval periods. Four temporally coherent networks (TCNs)—the default mode network (DMN), the dorsal attention, the right and the left WM network—were extracted from the continuous BOLD data by means of a group ICA. Subsequently, the modulatory effect of these networks' pre-stimulus activation upon retention-related EEG activity in the theta, alpha, and beta frequencies was analyzed. The obtained results are informative in the context of state-dependent information processing. We were able to replicate two well-known load-dependent effects: the frontal-midline theta increase during the task and the decrease of pre-stimulus DMN activity. As our main finding, these two measures seem to depend on each other as the significant negative correlations at frontal-midline channels suggested. Thus, suppressed pre-stimulus DMN levels facilitated later task related frontal midline theta increases. In general, based on previous findings that neuronal coupling in different frequency bands may underlie distinct functions in WM retention, our results suggest that processes reflected by spectral oscillations during retention seem not only to be “online” synchronized with activity in different attention-related networks but are also modulated by activity in these networks during preparation intervals. Frontiers Media S.A. 2015-05-06 /pmc/articles/PMC4422031/ /pubmed/25999828 http://dx.doi.org/10.3389/fnbeh.2015.00111 Text en Copyright © 2015 Kottlow, Schlaepfer, Baenninger, Michels, Brandeis and Koenig. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Kottlow, Mara
Schlaepfer, Anthony
Baenninger, Anja
Michels, Lars
Brandeis, Daniel
Koenig, Thomas
Pre-stimulus BOLD-network activation modulates EEG spectral activity during working memory retention
title Pre-stimulus BOLD-network activation modulates EEG spectral activity during working memory retention
title_full Pre-stimulus BOLD-network activation modulates EEG spectral activity during working memory retention
title_fullStr Pre-stimulus BOLD-network activation modulates EEG spectral activity during working memory retention
title_full_unstemmed Pre-stimulus BOLD-network activation modulates EEG spectral activity during working memory retention
title_short Pre-stimulus BOLD-network activation modulates EEG spectral activity during working memory retention
title_sort pre-stimulus bold-network activation modulates eeg spectral activity during working memory retention
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422031/
https://www.ncbi.nlm.nih.gov/pubmed/25999828
http://dx.doi.org/10.3389/fnbeh.2015.00111
work_keys_str_mv AT kottlowmara prestimulusboldnetworkactivationmodulateseegspectralactivityduringworkingmemoryretention
AT schlaepferanthony prestimulusboldnetworkactivationmodulateseegspectralactivityduringworkingmemoryretention
AT baenningeranja prestimulusboldnetworkactivationmodulateseegspectralactivityduringworkingmemoryretention
AT michelslars prestimulusboldnetworkactivationmodulateseegspectralactivityduringworkingmemoryretention
AT brandeisdaniel prestimulusboldnetworkactivationmodulateseegspectralactivityduringworkingmemoryretention
AT koenigthomas prestimulusboldnetworkactivationmodulateseegspectralactivityduringworkingmemoryretention