Two Susceptibility Loci Identified for Prostate Cancer Aggressiveness

Most men diagnosed with prostate cancer will experience indolent disease; hence discovering genetic variants that distinguish aggressive from non-aggressive prostate cancer is of critical clinical importance for disease prevention and treatment. In a multistage, case-only genome-wide association stu...

Descripción completa

Detalles Bibliográficos
Autores principales: Berndt, Sonja I., Wang, Zhaoming, Yeager, Meredith, Alavanja, Michael C., Albanes, Demetrius, Amundadottir, Laufey, Andriole, Gerald, Freeman, Laura Beane, Campa, Daniele, Cancel-Tassin, Geraldine, Canzian, Federico, Cornu, Jean-Nicolas, Cussenot, Olivier, Diver, W. Ryan, Gapstur, Susan M., Grönberg, Henrik, Haiman, Christopher A., Henderson, Brian, Hutchinson, Amy, Hunter, David J., Key, Timothy J., Kolb, Suzanne, Koutros, Stella, Kraft, Peter, Le Marchand, Loic, Lindström, Sara, Machiela, Mitchell J., Ostrander, Elaine A., Riboli, Elio, Schumacher, Fred, Siddiq, Afshan, Stanford, Janet L., Stevens, Victoria L., Travis, Ruth C., Tsilidis, Konstantinos K., Virtamo, Jarmo, Weinstein, Stephanie, Wilkund, Fredrik, Xu, Jianfeng, Zheng, S. Lilly, Yu, Kai, Wheeler, William, Zhang, Han, Sampson, Joshua, Black, Amanda, Jacobs, Kevin, Hoover, Robert N, Tucker, Margaret, Chanock, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422072/
https://www.ncbi.nlm.nih.gov/pubmed/25939597
http://dx.doi.org/10.1038/ncomms7889
Descripción
Sumario:Most men diagnosed with prostate cancer will experience indolent disease; hence discovering genetic variants that distinguish aggressive from non-aggressive prostate cancer is of critical clinical importance for disease prevention and treatment. In a multistage, case-only genome-wide association study of 12,518 prostate cancer cases, we identify two loci associated with Gleason score, a pathological measure of disease aggressiveness: rs35148638 at 5q14.3 (RASA1, P=6.49×10(-9)) and rs78943174 at 3q26.31 (NAALADL2, P=4.18×10(-8)). In a stratified case-control analysis, the SNP at 5q14.3 appears specific for aggressive prostate cancer (P=8.85×10(-5)) with no association for non-aggressive prostate cancer compared to controls (P=0.57). The proximity of these loci to genes involved in vascular disease suggests potential biological mechanisms worthy of further investigation.

Ejemplares similares