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Two Susceptibility Loci Identified for Prostate Cancer Aggressiveness
Most men diagnosed with prostate cancer will experience indolent disease; hence discovering genetic variants that distinguish aggressive from non-aggressive prostate cancer is of critical clinical importance for disease prevention and treatment. In a multistage, case-only genome-wide association stu...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422072/ https://www.ncbi.nlm.nih.gov/pubmed/25939597 http://dx.doi.org/10.1038/ncomms7889 |
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| author | Berndt, Sonja I. Wang, Zhaoming Yeager, Meredith Alavanja, Michael C. Albanes, Demetrius Amundadottir, Laufey Andriole, Gerald Freeman, Laura Beane Campa, Daniele Cancel-Tassin, Geraldine Canzian, Federico Cornu, Jean-Nicolas Cussenot, Olivier Diver, W. Ryan Gapstur, Susan M. Grönberg, Henrik Haiman, Christopher A. Henderson, Brian Hutchinson, Amy Hunter, David J. Key, Timothy J. Kolb, Suzanne Koutros, Stella Kraft, Peter Le Marchand, Loic Lindström, Sara Machiela, Mitchell J. Ostrander, Elaine A. Riboli, Elio Schumacher, Fred Siddiq, Afshan Stanford, Janet L. Stevens, Victoria L. Travis, Ruth C. Tsilidis, Konstantinos K. Virtamo, Jarmo Weinstein, Stephanie Wilkund, Fredrik Xu, Jianfeng Zheng, S. Lilly Yu, Kai Wheeler, William Zhang, Han Sampson, Joshua Black, Amanda Jacobs, Kevin Hoover, Robert N Tucker, Margaret Chanock, Stephen J. |
| author_facet | Berndt, Sonja I. Wang, Zhaoming Yeager, Meredith Alavanja, Michael C. Albanes, Demetrius Amundadottir, Laufey Andriole, Gerald Freeman, Laura Beane Campa, Daniele Cancel-Tassin, Geraldine Canzian, Federico Cornu, Jean-Nicolas Cussenot, Olivier Diver, W. Ryan Gapstur, Susan M. Grönberg, Henrik Haiman, Christopher A. Henderson, Brian Hutchinson, Amy Hunter, David J. Key, Timothy J. Kolb, Suzanne Koutros, Stella Kraft, Peter Le Marchand, Loic Lindström, Sara Machiela, Mitchell J. Ostrander, Elaine A. Riboli, Elio Schumacher, Fred Siddiq, Afshan Stanford, Janet L. Stevens, Victoria L. Travis, Ruth C. Tsilidis, Konstantinos K. Virtamo, Jarmo Weinstein, Stephanie Wilkund, Fredrik Xu, Jianfeng Zheng, S. Lilly Yu, Kai Wheeler, William Zhang, Han Sampson, Joshua Black, Amanda Jacobs, Kevin Hoover, Robert N Tucker, Margaret Chanock, Stephen J. |
| author_sort | Berndt, Sonja I. |
| collection | PubMed |
| description | Most men diagnosed with prostate cancer will experience indolent disease; hence discovering genetic variants that distinguish aggressive from non-aggressive prostate cancer is of critical clinical importance for disease prevention and treatment. In a multistage, case-only genome-wide association study of 12,518 prostate cancer cases, we identify two loci associated with Gleason score, a pathological measure of disease aggressiveness: rs35148638 at 5q14.3 (RASA1, P=6.49×10(-9)) and rs78943174 at 3q26.31 (NAALADL2, P=4.18×10(-8)). In a stratified case-control analysis, the SNP at 5q14.3 appears specific for aggressive prostate cancer (P=8.85×10(-5)) with no association for non-aggressive prostate cancer compared to controls (P=0.57). The proximity of these loci to genes involved in vascular disease suggests potential biological mechanisms worthy of further investigation. |
| format | Online Article Text |
| id | pubmed-4422072 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-44220722015-11-05 Two Susceptibility Loci Identified for Prostate Cancer Aggressiveness Berndt, Sonja I. Wang, Zhaoming Yeager, Meredith Alavanja, Michael C. Albanes, Demetrius Amundadottir, Laufey Andriole, Gerald Freeman, Laura Beane Campa, Daniele Cancel-Tassin, Geraldine Canzian, Federico Cornu, Jean-Nicolas Cussenot, Olivier Diver, W. Ryan Gapstur, Susan M. Grönberg, Henrik Haiman, Christopher A. Henderson, Brian Hutchinson, Amy Hunter, David J. Key, Timothy J. Kolb, Suzanne Koutros, Stella Kraft, Peter Le Marchand, Loic Lindström, Sara Machiela, Mitchell J. Ostrander, Elaine A. Riboli, Elio Schumacher, Fred Siddiq, Afshan Stanford, Janet L. Stevens, Victoria L. Travis, Ruth C. Tsilidis, Konstantinos K. Virtamo, Jarmo Weinstein, Stephanie Wilkund, Fredrik Xu, Jianfeng Zheng, S. Lilly Yu, Kai Wheeler, William Zhang, Han Sampson, Joshua Black, Amanda Jacobs, Kevin Hoover, Robert N Tucker, Margaret Chanock, Stephen J. Nat Commun Article Most men diagnosed with prostate cancer will experience indolent disease; hence discovering genetic variants that distinguish aggressive from non-aggressive prostate cancer is of critical clinical importance for disease prevention and treatment. In a multistage, case-only genome-wide association study of 12,518 prostate cancer cases, we identify two loci associated with Gleason score, a pathological measure of disease aggressiveness: rs35148638 at 5q14.3 (RASA1, P=6.49×10(-9)) and rs78943174 at 3q26.31 (NAALADL2, P=4.18×10(-8)). In a stratified case-control analysis, the SNP at 5q14.3 appears specific for aggressive prostate cancer (P=8.85×10(-5)) with no association for non-aggressive prostate cancer compared to controls (P=0.57). The proximity of these loci to genes involved in vascular disease suggests potential biological mechanisms worthy of further investigation. 2015-05-05 /pmc/articles/PMC4422072/ /pubmed/25939597 http://dx.doi.org/10.1038/ncomms7889 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Berndt, Sonja I. Wang, Zhaoming Yeager, Meredith Alavanja, Michael C. Albanes, Demetrius Amundadottir, Laufey Andriole, Gerald Freeman, Laura Beane Campa, Daniele Cancel-Tassin, Geraldine Canzian, Federico Cornu, Jean-Nicolas Cussenot, Olivier Diver, W. Ryan Gapstur, Susan M. Grönberg, Henrik Haiman, Christopher A. Henderson, Brian Hutchinson, Amy Hunter, David J. Key, Timothy J. Kolb, Suzanne Koutros, Stella Kraft, Peter Le Marchand, Loic Lindström, Sara Machiela, Mitchell J. Ostrander, Elaine A. Riboli, Elio Schumacher, Fred Siddiq, Afshan Stanford, Janet L. Stevens, Victoria L. Travis, Ruth C. Tsilidis, Konstantinos K. Virtamo, Jarmo Weinstein, Stephanie Wilkund, Fredrik Xu, Jianfeng Zheng, S. Lilly Yu, Kai Wheeler, William Zhang, Han Sampson, Joshua Black, Amanda Jacobs, Kevin Hoover, Robert N Tucker, Margaret Chanock, Stephen J. Two Susceptibility Loci Identified for Prostate Cancer Aggressiveness |
| title | Two Susceptibility Loci Identified for Prostate Cancer Aggressiveness |
| title_full | Two Susceptibility Loci Identified for Prostate Cancer Aggressiveness |
| title_fullStr | Two Susceptibility Loci Identified for Prostate Cancer Aggressiveness |
| title_full_unstemmed | Two Susceptibility Loci Identified for Prostate Cancer Aggressiveness |
| title_short | Two Susceptibility Loci Identified for Prostate Cancer Aggressiveness |
| title_sort | two susceptibility loci identified for prostate cancer aggressiveness |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422072/ https://www.ncbi.nlm.nih.gov/pubmed/25939597 http://dx.doi.org/10.1038/ncomms7889 |
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