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Total thyroidectomy as a method of choice in the treatment of Graves’ disease - analysis of 1432 patients

BACKGROUND: Graves’ disease represents an autoimmune disease of the thyroid gland where surgery has an important role in its treatment. The aim of our paper was to analyze the results of surgical treatment, the frequency of microcarcinoma and carcinoma, as well as to compare surgical complications i...

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Autores principales: Bojic, Toplica, Paunovic, Ivan, Diklic, Aleksandar, Zivaljevic, Vladan, Zoric, Goran, Kalezic, Nevena, Sabljak, Vera, Slijepcevic, Nikola, Tausanovic, Katarina, Djordjevic, Nebojsa, Budjevac, Dragana, Djordjevic, Lidija, Karanikolic, Aleksandar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422312/
https://www.ncbi.nlm.nih.gov/pubmed/25888210
http://dx.doi.org/10.1186/s12893-015-0023-3
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author Bojic, Toplica
Paunovic, Ivan
Diklic, Aleksandar
Zivaljevic, Vladan
Zoric, Goran
Kalezic, Nevena
Sabljak, Vera
Slijepcevic, Nikola
Tausanovic, Katarina
Djordjevic, Nebojsa
Budjevac, Dragana
Djordjevic, Lidija
Karanikolic, Aleksandar
author_facet Bojic, Toplica
Paunovic, Ivan
Diklic, Aleksandar
Zivaljevic, Vladan
Zoric, Goran
Kalezic, Nevena
Sabljak, Vera
Slijepcevic, Nikola
Tausanovic, Katarina
Djordjevic, Nebojsa
Budjevac, Dragana
Djordjevic, Lidija
Karanikolic, Aleksandar
author_sort Bojic, Toplica
collection PubMed
description BACKGROUND: Graves’ disease represents an autoimmune disease of the thyroid gland where surgery has an important role in its treatment. The aim of our paper was to analyze the results of surgical treatment, the frequency of microcarcinoma and carcinoma, as well as to compare surgical complications in relation to the various types of operations performed for Graves’ disease. METHODS: We analysed 1432 patients (221 male and 1211 female) who underwent surgery for Graves’ disease at the Centre for Endocrine Surgery in Belgrade during 15 years (1996–2010). Average age was 34.8 years. Frequency of surgical complications within the groups was analyzed with nonparametric Fisher’s test. RESULTS: Total thyroidectomy (TT) was performed in 974 (68%) patients, and Dunhill operation (D) in 221 (15.4). Carcinoma of thyroid gland was found in 146 patients (10.2%), of which 129 (9%) were a microcarcinoma. Complication rates were higher in the TT group, where there were 31 (3.2%) patients with permanent hypoparathyroidism, 9 (0.9%) patients with unilateral recurrent nerve paralysis and 10 (1.0%) patients with postoperative bleeding. Combined complications, such as permanent hypoparathyroidism with bleeding were more common in the D group where there were 2 patients (0,9%), while unilateral recurrent nerve paralysis with bleeding was more common in the TT group where there were 3 cases (0,3%). CONCLUSIONS: Frequency of complications were not significantly statistically different in relation to the type of surgical procedure. Total thyroidectomy represents a safe and efficient method for treating patients with Graves’ disease, and it is not followed by a greater frequency of complications in relation to less extensive procedures.
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spelling pubmed-44223122015-05-07 Total thyroidectomy as a method of choice in the treatment of Graves’ disease - analysis of 1432 patients Bojic, Toplica Paunovic, Ivan Diklic, Aleksandar Zivaljevic, Vladan Zoric, Goran Kalezic, Nevena Sabljak, Vera Slijepcevic, Nikola Tausanovic, Katarina Djordjevic, Nebojsa Budjevac, Dragana Djordjevic, Lidija Karanikolic, Aleksandar BMC Surg Research Article BACKGROUND: Graves’ disease represents an autoimmune disease of the thyroid gland where surgery has an important role in its treatment. The aim of our paper was to analyze the results of surgical treatment, the frequency of microcarcinoma and carcinoma, as well as to compare surgical complications in relation to the various types of operations performed for Graves’ disease. METHODS: We analysed 1432 patients (221 male and 1211 female) who underwent surgery for Graves’ disease at the Centre for Endocrine Surgery in Belgrade during 15 years (1996–2010). Average age was 34.8 years. Frequency of surgical complications within the groups was analyzed with nonparametric Fisher’s test. RESULTS: Total thyroidectomy (TT) was performed in 974 (68%) patients, and Dunhill operation (D) in 221 (15.4). Carcinoma of thyroid gland was found in 146 patients (10.2%), of which 129 (9%) were a microcarcinoma. Complication rates were higher in the TT group, where there were 31 (3.2%) patients with permanent hypoparathyroidism, 9 (0.9%) patients with unilateral recurrent nerve paralysis and 10 (1.0%) patients with postoperative bleeding. Combined complications, such as permanent hypoparathyroidism with bleeding were more common in the D group where there were 2 patients (0,9%), while unilateral recurrent nerve paralysis with bleeding was more common in the TT group where there were 3 cases (0,3%). CONCLUSIONS: Frequency of complications were not significantly statistically different in relation to the type of surgical procedure. Total thyroidectomy represents a safe and efficient method for treating patients with Graves’ disease, and it is not followed by a greater frequency of complications in relation to less extensive procedures. BioMed Central 2015-04-09 /pmc/articles/PMC4422312/ /pubmed/25888210 http://dx.doi.org/10.1186/s12893-015-0023-3 Text en © Bojic et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Bojic, Toplica
Paunovic, Ivan
Diklic, Aleksandar
Zivaljevic, Vladan
Zoric, Goran
Kalezic, Nevena
Sabljak, Vera
Slijepcevic, Nikola
Tausanovic, Katarina
Djordjevic, Nebojsa
Budjevac, Dragana
Djordjevic, Lidija
Karanikolic, Aleksandar
Total thyroidectomy as a method of choice in the treatment of Graves’ disease - analysis of 1432 patients
title Total thyroidectomy as a method of choice in the treatment of Graves’ disease - analysis of 1432 patients
title_full Total thyroidectomy as a method of choice in the treatment of Graves’ disease - analysis of 1432 patients
title_fullStr Total thyroidectomy as a method of choice in the treatment of Graves’ disease - analysis of 1432 patients
title_full_unstemmed Total thyroidectomy as a method of choice in the treatment of Graves’ disease - analysis of 1432 patients
title_short Total thyroidectomy as a method of choice in the treatment of Graves’ disease - analysis of 1432 patients
title_sort total thyroidectomy as a method of choice in the treatment of graves’ disease - analysis of 1432 patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422312/
https://www.ncbi.nlm.nih.gov/pubmed/25888210
http://dx.doi.org/10.1186/s12893-015-0023-3
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