Cargando…

Th1-Like ICOS(+) Foxp3(+) T(reg) Cells Preferentially Express CXCR3 and Home to β-Islets during Pre-Diabetes in BDC2.5 NOD Mice

Type 1 diabetes (T1D) occurs through a breakdown of self-tolerance resulting in the autoimmune destruction of the insulin producing β-islets of the pancreas. A numerical and functional waning of CD4(+)Foxp3(+) regulatory T (T(reg)) cells, prompted by a pancreatic IL-2 deficiency, accompanies Th1 aut...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kornete, Mara, Mason, Edward S., Girouard, Julien, Lafferty, Erin I., Qureshi, Salman, Piccirillo, Ciriaco A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422433/ https://www.ncbi.nlm.nih.gov/pubmed/25946021 http://dx.doi.org/10.1371/journal.pone.0126311

Ejemplares similares

Functional crosstalk between dendritic cells and Foxp3(+) regulatory T cells in the maintenance of immune tolerance
por: Kornete, Mara, et al.
Publicado: (2012)

Immune Regulation in T1D and T2D: Prospective Role of Foxp3+ Treg Cells in Disease Pathogenesis and Treatment
por: Kornete, Mara, et al.
Publicado: (2013)

IL-2 as a therapeutic target for the restoration of Foxp3(+ )regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease
por: d'Hennezel, Eva, et al.
Publicado: (2010)

Plasmodium chabaudi AS Infection Induces CD4(+) Th1 Cells and Foxp3(+)T-bet(+) Regulatory T Cells That Express CXCR3 and Migrate to CXCR3 Ligands
por: Berretta, Floriana, et al.
Publicado: (2019)

Mechanisms of human FoxP3(+) T(reg) cell development and function in health and disease
por: Attias, M., et al.
Publicado: (2019)

FOXP3 and Tip60 Structural Interactions Relevant to IPEX Development Lead to Potential Therapeutics to Increase FOXP3 Dependent Suppressor T Cell Functions
por: Grover, Payal, et al.
Publicado: (2021)

S-nitrosoglutathione modulates CXCR4 and ICOS expression
por: Yamamoto, Yoshihiko, et al.
Publicado: (2006)

ICOS signal facilitates Foxp3 transcription to favor suppressive function of regulatory T cells
por: Chen, Qianmei, et al.
Publicado: (2018)

Foxp3 Post-translational Modifications and Treg Suppressive Activity
por: Deng, Guoping, et al.
Publicado: (2019)

Suppressive IL-17A(+)Foxp3(+) and ex-Th17 IL-17A(neg)Foxp3(+) T(reg) cells are a source of tumour-associated T(reg) cells
por: Downs-Canner, Stephanie, et al.
Publicado: (2017)

FoxP3 in T(reg) cell biology: a molecular and structural perspective
por: Deng, G., et al.
Publicado: (2019)

Signaling Through gp130 Compromises Suppressive Function in Human FOXP3(+) Regulatory T Cells
por: Bin Dhuban, Khalid, et al.
Publicado: (2019)

Infected site-restricted Foxp3(+) natural regulatory T cells are specific for microbial antigens
por: Suffia, Isabelle J., et al.
Publicado: (2006)

CD4(+)ICOS(+)Foxp3(+): a sub-population of regulatory T cells contribute to malaria pathogenesis
por: Chauhan, Rubika, et al.
Publicado: (2022)

β-Cell–Specific IL-2 Therapy Increases Islet Foxp3(+)Treg and Suppresses Type 1 Diabetes in NOD Mice
por: Johnson, Mark C., et al.
Publicado: (2013)

ICOS controls Foxp3(+) regulatory T-cell expansion, maintenance and IL-10 production during helminth infection
por: Redpath, Stephen A, et al.
Publicado: (2013)

Regulatory T cells, especially ICOS(+) FOXP3(+) regulatory T cells, are increased in the hepatocellular carcinoma microenvironment and predict reduced survival
por: Tu, Jian-Fei, et al.
Publicado: (2016)

BDC12-4.1 T-Cell Receptor Transgenic Insulin-Specific CD4 T Cells Are Resistant to In Vitro Differentiation into Functional Foxp3(+) T Regulatory Cells
por: Sarikonda, Ghanashyam, et al.
Publicado: (2014)

BDC 500 branch driver controller
por: Dijksman, A, et al.
Publicado: (1981)

Cu-BDC and Cu(2)O Derived from Cu-BDC for the Removal and Oxidation of Asphaltenes: A Comparative Study
por: Nayak, Abhishek, et al.
Publicado: (2022)

CD44 expression positively correlates with Foxp3 expression and suppressive function of CD4(+ )T(reg )cells
por: Liu, Tie, et al.
Publicado: (2009)

A negative role for the interleukin-2-inducible T-cell kinase (ITK) in human Foxp3(+) T(REG) differentiation
por: Mamontov, Polina, et al.
Publicado: (2019)

TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity
por: Sun, Xiang, et al.
Publicado: (2019)

ICOS(+)PD-1(+)CXCR3(+) T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccination
por: Bentebibel, Salah-Eddine, et al.
Publicado: (2016)

Peripherally induced Foxp3(+) regulatory T cells mediates the immunomodulatory effect of intravenous immunoglobulin in an experimental model of allergic airway disease
por: Massoud, Amir H, et al.
Publicado: (2014)

Recombinant Reg3α Prevents Islet β-Cell Apoptosis and Promotes β-Cell Regeneration
por: Yu, Luting, et al.
Publicado: (2022)

Tunable Synthesis of Mesoporous Carbons from Fe(3)O(BDC)(3) for Chloramphenicol Antibiotic Remediation
por: Tran, Thuan Van, et al.
Publicado: (2019)

Synthesis and characterizations of YZ-BDC:Eu(3+),Tb(3+) nanothermometers for luminescence-based temperature sensing
por: Kieu Giang, Lam Thi, et al.
Publicado: (2022)

IL‐3 is essential for ICOS‐L stabilization on mast cells, and sustains the IL‐33‐induced RORγt(+) T(reg) generation via enhanced IL‐6 induction
por: Drube, Sebastian, et al.
Publicado: (2021)

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4(+) T reg cells
por: Liu, Weihong, et al.
Publicado: (2006)

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3(+) T reg cells
por: Weiss, Jonathan M., et al.
Publicado: (2012)

Foxp3(+) T reg cells control psoriasiform inflammation by restraining an IFN-I–driven CD8(+) T cell response
por: Stockenhuber, Krista, et al.
Publicado: (2018)

ICO investors
por: Fahlenbrach, Rüdiger, et al.
Publicado: (2020)

Correction: Synthesis and characterizations of YZ-BDC:Eu(3+),Tb(3+) nanothermometers for luminescence-based temperature sensing
por: Kieu Giang, Lam Thi, et al.
Publicado: (2022)

Organically pillared layer framework of [Eu(NH(2)–BDC)(ox)(H(3)O)]
por: Thammakan, Supaphorn, et al.
Publicado: (2019)

Novel magnetic nanocomposites BiFeO(3)/Cu(BDC) for efficient dye removal
por: Shahrab, Fatemeh, et al.
Publicado: (2023)

Islet amyloid deposits preferentially in the highly functional and most blood-perfused islets
por: Ullsten, Sara, et al.
Publicado: (2017)

FoxP3 Interacts with Linker Histone H1.5 to Modulate Gene Expression and Program T(reg) Cell Activity
por: Mackey-Cushman, Stephanie L., et al.
Publicado: (2011)

Enforced Expression of CXCR5 Drives T Follicular Regulatory-Like Features in Foxp3(+) T Cells
por: Kim, Young Uk, et al.
Publicado: (2017)

Regenerating islet-derived protein (Reg)3β plays a crucial role in attenuation of ileitis and colitis in mice
por: Shindo, Ryodai, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_l1tk7tpno7bop0bnhuiamj8un4