Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer

BACKGROUND: Common genetic variants residing near upstream regulatory elements for MYB, the gene encoding transcription factor cMYB, promote the persistence of fetal hemoglobin (HbF) into adulthood. While they have no consequences in healthy individuals, high HbF levels have major clinical benefits...

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Detalles Bibliográficos
Autores principales: Mtatiro, Siana N, Mgaya, Josephine, Singh, Tarjinder, Mariki, Harvest, Rooks, Helen, Soka, Deogratius, Mmbando, Bruno, Thein, Swee Lay, Barrett, Jeffrey C, Makani, Julie, Cox, Sharon E, Menzel, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422446/
https://www.ncbi.nlm.nih.gov/pubmed/25928412
http://dx.doi.org/10.1186/s12881-015-0148-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422446/
https://www.ncbi.nlm.nih.gov/pubmed/25928412
http://dx.doi.org/10.1186/s12881-015-0148-3

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