Cargando…

Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer

BACKGROUND: Common genetic variants residing near upstream regulatory elements for MYB, the gene encoding transcription factor cMYB, promote the persistence of fetal hemoglobin (HbF) into adulthood. While they have no consequences in healthy individuals, high HbF levels have major clinical benefits...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mtatiro, Siana N, Mgaya, Josephine, Singh, Tarjinder, Mariki, Harvest, Rooks, Helen, Soka, Deogratius, Mmbando, Bruno, Thein, Swee Lay, Barrett, Jeffrey C, Makani, Julie, Cox, Sharon E, Menzel, Stephan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422446/ https://www.ncbi.nlm.nih.gov/pubmed/25928412 http://dx.doi.org/10.1186/s12881-015-0148-3

Ejemplares similares

Genome Wide Association Study of Fetal Hemoglobin in Sickle Cell Anemia in Tanzania
por: Mtatiro, Siana Nkya, et al.
Publicado: (2014)

Genetic variants at HbF‐modifier loci moderate anemia and leukocytosis in sickle cell disease in Tanzania
por: Mtatiro, Siana Nkya, et al.
Publicado: (2014)

Fetal Hemoglobin is Associated with Peripheral Oxygen Saturation in Sickle Cell Disease in Tanzania
por: Nkya, Siana, et al.
Publicado: (2017)

A ten year review of the sickle cell program in Muhimbili National Hospital, Tanzania
por: Makani, Julie, et al.
Publicado: (2018)

Identifying genetic variants and pathways associated with extreme levels of fetal hemoglobin in sickle cell disease in Tanzania
por: Nkya, Siana, et al.
Publicado: (2020)

Negative Epistasis between Sickle and Foetal Haemoglobin Suggests a Reduction in Protection against Malaria
por: Mmbando, Bruno P., et al.
Publicado: (2015)

Mortality in Sickle Cell Anemia in Africa: A Prospective Cohort Study in Tanzania
por: Makani, Julie, et al.
Publicado: (2011)

Patterns and patient factors associated with loss to follow-up in the Muhimbili sickle cell cohort, Tanzania
por: Masamu, Upendo, et al.
Publicado: (2020)

Global Genetic Architecture of an Erythroid Quantitative Trait Locus, HMIP-2
por: Menzel, Stephan, et al.
Publicado: (2014)

Peripheral vascular response to inspiratory breath hold in paediatric homozygous sickle cell disease
por: L’Esperance, Veline S, et al.
Publicado: (2013)

Bacteraemia in sickle cell anaemia is associated with low haemoglobin: a report of 890 admissions to a tertiary hospital in Tanzania
por: Makani, Julie, et al.
Publicado: (2015)

Experimental Generation of SNP Haplotype Signatures in Patients with Sickle Cell Anaemia
por: Menzel, Stephan, et al.
Publicado: (2010)

A survey of genetic fetal-haemoglobin modifiers in Nigerian patients with sickle cell anaemia
por: Adeyemo, Titilope A., et al.
Publicado: (2018)

COVID-19 and sickle cell disease
por: Menapace, Laurel A., et al.
Publicado: (2020)

Perspectives on Building Sustainable Newborn Screening Programs for Sickle Cell Disease: Experience from Tanzania
por: Bukini, Daima, et al.
Publicado: (2021)

Genome wide association study of silent cerebral infarction in sickle cell disease (HbSS and HbSC)
por: Brewin, John N., et al.
Publicado: (2020)

Therapeutic advances in sickle cell disease in the last decade
por: Shet, Arun S., et al.
Publicado: (2017)

Prevalence and Factors Associated with Human Parvovirus B19 Infection in Sickle Cell Patients Hospitalized in Tanzania
por: Urio, Florence, et al.
Publicado: (2019)

Using DNA testing for the precise, definite, and low-cost diagnosis of sickle cell disease and other Haemoglobinopathies: findings from Tanzania
por: Christopher, Heavenlight, et al.
Publicado: (2021)

Post-translational modification as a response to cellular stress induced by hemoglobin oxidation in sickle cell disease
por: Strader, Michael Brad, et al.
Publicado: (2020)

Health policy for sickle cell disease in Africa: experience from Tanzania on interventions to reduce under-five mortality
por: Makani, Julie, et al.
Publicado: (2014)

Relationships between sickle cell trait, malaria, and educational outcomes in Tanzania
por: Croke, Kevin, et al.
Publicado: (2017)

The carrier state for sickle cell disease is not completely harmless
por: Xu, Julia Zhe, et al.
Publicado: (2019)

Research in Sickle Cell Disease: From Bedside to Bench to Bedside
por: Salinas Cisneros, Gabriel, et al.
Publicado: (2021)

Decreased Hepcidin Levels Are Associated with Low Steady-state Hemoglobin in Children With Sickle Cell Disease in Tanzania
por: Lee, Nathaniel, et al.
Publicado: (2018)

Possible Risk Factors for Severe Anemia in Hospitalized Sickle Cell Patients at Muhimbili National Hospital, Tanzania: Protocol for a Cross-Sectional Study
por: Tluway, Furahini, et al.
Publicado: (2018)

Proteomic analysis of plasma from children with sickle cell anemia and silent cerebral infarction
por: Tewari, Sanjay, et al.
Publicado: (2018)

Building research capacity for sickle cell disease in Africa: Lessons and challenges from establishing a birth cohort in Tanzania
por: Nkya, Siana, et al.
Publicado: (2022)

Allosteric control of hemoglobin S fiber formation by oxygen and its relation to the pathophysiology of sickle cell disease
por: Henry, Eric R., et al.
Publicado: (2020)

Neutrophils remain detrimentally active in hydroxyurea-treated patients with sickle cell disease
por: Barbu, Emilia Alina, et al.
Publicado: (2019)

World Sickle Cell Day 2016 : A time for appraisal
por: Thein, Mya S., et al.
Publicado: (2016)

Rationale and design of mDOT-HuA study: a randomized trial to assess the effect of mobile-directly observed therapy on adherence to hydroxyurea in adults with sickle cell anemia in Tanzania
por: Makubi, Abel, et al.
Publicado: (2016)

Genetic variants of PKLR are associated with acute pain in sickle cell disease
por: Wang, Xunde, et al.
Publicado: (2022)

Haptoglobin, alpha‐thalassaemia and glucose‐6‐phosphate dehydrogenase polymorphisms and risk of abnormal transcranial Doppler among patients with sickle cell anaemia in Tanzania
por: Cox, Sharon E., et al.
Publicado: (2014)

Nocturnal haemoglobin oxygen saturation variability is associated with vitamin C deficiency in Tanzanian children with sickle cell anaemia
por: Cox, SE, et al.
Publicado: (2011)

Prevalence of Hemoglobin-S and Baseline Level of Knowledge on Sickle Cell Disease Among Pregnant Women Attending Antenatal Clinics in Dar-Es-Salaam, Tanzania
por: Tutuba, Hilda J., et al.
Publicado: (2022)

Recent Advances in the Treatment of Sickle Cell Disease
por: Salinas Cisneros, Gabriel, et al.
Publicado: (2020)

Rationale, design and protocol of a cross-sectional study on pregnancy-related cardiovascular diseases in Tanzania (PRECARDT): burden, characterisation and prognostic significance at delivery
por: Makubi, Abel, et al.
Publicado: (2021)

Increased prevalence of renal cysts in patients with sickle cell disease
por: Meeks, Daveena, et al.
Publicado: (2017)

Development of multi-level standards of care recommendations for sickle cell disease: Experience from SickleInAfrica
por: Paintsil, Vivian, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_pf5aa5lmnikojpikqh44a769ou