Medicinal value of asiaticoside for Alzheimer’s disease as assessed using single-molecule-detection fluorescence correlation spectroscopy, laser-scanning microscopy, transmission electron microscopy, and in silico docking

BACKGROUND: Identifying agents that inhibit amyloid beta peptide (Aβ) aggregation is the ultimate goal for slowing Alzheimer’s disease (AD) progression. This study investigated whether the glycoside asiaticoside inhibits Aβ(1–42) fibrillation in vitro. METHODS: Fluorescence correlation spectroscopy...

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Detalles Bibliográficos
Autores principales: Hossain, Shahdat, Hashimoto, Michio, Katakura, Masanori, Al Mamun, Abdullah, Shido, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422550/
https://www.ncbi.nlm.nih.gov/pubmed/25880304
http://dx.doi.org/10.1186/s12906-015-0620-9

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