A growth-rate composition formula for the growth of E. coli on co-utilized carbon substrates

When bacteria are cultured in medium with multiple carbon substrates, they frequently consume these substrates simultaneously. Building on recent advances in the understanding of metabolic coordination exhibited by Escherichia coli cells through cAMP-Crp signaling, we show that this signaling system...

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Detalles Bibliográficos
Autores principales: Hermsen, Rutger, Okano, Hiroyuki, You, Conghui, Werner, Nicole, Hwa, Terence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422558/
https://www.ncbi.nlm.nih.gov/pubmed/25862745
http://dx.doi.org/10.15252/msb.20145537
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author Hermsen, Rutger
Okano, Hiroyuki
You, Conghui
Werner, Nicole
Hwa, Terence
author_facet Hermsen, Rutger
Okano, Hiroyuki
You, Conghui
Werner, Nicole
Hwa, Terence
author_sort Hermsen, Rutger
collection PubMed
description When bacteria are cultured in medium with multiple carbon substrates, they frequently consume these substrates simultaneously. Building on recent advances in the understanding of metabolic coordination exhibited by Escherichia coli cells through cAMP-Crp signaling, we show that this signaling system responds to the total carbon-uptake flux when substrates are co-utilized and derive a mathematical formula that accurately predicts the resulting growth rate, based only on the growth rates on individual substrates.
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spelling pubmed-44225582015-05-12 A growth-rate composition formula for the growth of E. coli on co-utilized carbon substrates Hermsen, Rutger Okano, Hiroyuki You, Conghui Werner, Nicole Hwa, Terence Mol Syst Biol Reports When bacteria are cultured in medium with multiple carbon substrates, they frequently consume these substrates simultaneously. Building on recent advances in the understanding of metabolic coordination exhibited by Escherichia coli cells through cAMP-Crp signaling, we show that this signaling system responds to the total carbon-uptake flux when substrates are co-utilized and derive a mathematical formula that accurately predicts the resulting growth rate, based only on the growth rates on individual substrates. BlackWell Publishing Ltd 2015-04-10 /pmc/articles/PMC4422558/ /pubmed/25862745 http://dx.doi.org/10.15252/msb.20145537 Text en © 2015 The Authors. Published under the terms of the CC BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reports
Hermsen, Rutger
Okano, Hiroyuki
You, Conghui
Werner, Nicole
Hwa, Terence
A growth-rate composition formula for the growth of E. coli on co-utilized carbon substrates
title A growth-rate composition formula for the growth of E. coli on co-utilized carbon substrates
title_full A growth-rate composition formula for the growth of E. coli on co-utilized carbon substrates
title_fullStr A growth-rate composition formula for the growth of E. coli on co-utilized carbon substrates
title_full_unstemmed A growth-rate composition formula for the growth of E. coli on co-utilized carbon substrates
title_short A growth-rate composition formula for the growth of E. coli on co-utilized carbon substrates
title_sort growth-rate composition formula for the growth of e. coli on co-utilized carbon substrates
topic Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422558/
https://www.ncbi.nlm.nih.gov/pubmed/25862745
http://dx.doi.org/10.15252/msb.20145537
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